Our training program brings together twenty faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi- disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested to that will be filled from outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics, Pathology, and Surgery) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Oncology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology, hematologic malignancies, and stem cells/transplantation. Expertise in vascular biology includes cellular and molecular hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, modeling of vessels and chemotaxis, clinical hemophilia and thrombophilia. Hematologic malignancy/stem cell biology is led by a prominent group of embryonic stem cell investigators. Expertise includes embryonic and induced pluripotent stem cells, leukemic stem cells, epigenetic regulation of hematopoiesis, signaling pathways, animal models in myeloma, clinical trials in lymphoma, tumor immunotherapy, and clinical stem cell applications in vascular and malignant disease. Training opportunities span basic and clinical investigation;including cutting edge technologies in genomics, proteomics, high throughput screening, microfluidics, murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical and Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Nine predoctoral appointees have now completed their Ph.D. degrees. Three are academic researchers, one is an industry scientist, one is a college chemistry instructor, one is postdoctoral scientist, and three are M.D.-Ph.D. students completing medical school/postgraduate training. Nineteen post- doctoral appointees have now completed training. Three are highly successful associate professors, six are assistant professors, two are academic scientists, and four are industry scientists. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.

Public Health Relevance

The training of future researchers in hematology is tremendously important to the development of the next generation of treatments for blood diseases. This training grant is especially important for training physicians and scientists that will study clinical problems related to bleeding, abnormal blood clot formation (deep vein clots, heart attacks, and strokes), low blood counts, and blood-based cancers.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007899-16
Application #
8608337
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1998-07-01
Project End
2019-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Madison
State
WI
Country
United States
Zip Code
53715
Hind, Laurel E; Ingram, Patrick N; Beebe, David J et al. (2018) Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa. Blood 132:1818-1828
Lieberman, Nicole A P; DeGolier, Kole; Haberthur, Kristen et al. (2018) An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells. Front Immunol 9:150
Turton, Keren B; Wilkerson, Emily M; Hebert, Alex S et al. (2018) Expression of novel ""LOCGEF"" isoforms of ARHGEF18 in eosinophils. J Leukoc Biol 104:135-145
Hernández-Santos, Nydiaris; Wiesner, Darin L; Fites, J Scott et al. (2018) Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe 23:511-522.e5
Lu, Li; Zhu, Fen; Zhang, Meili et al. (2018) Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A 115:E498-E505
Wolfe, Adam D; Capitini, Christian M; Salamat, Shahriar M et al. (2018) Neck Rhabdoid Tumors: Clinical Features and Consideration of Autologous Stem Cell Transplant. J Pediatr Hematol Oncol 40:e50-e54
Reidenbach, Andrew G; Kemmerer, Zachary A; Aydin, Deniz et al. (2018) Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. Cell Chem Biol 25:154-165.e11
Chanakira, Alice; Westmark, Pamela R; Ong, Irene M et al. (2017) Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer. Gynecol Oncol 145:167-175
Mosher, Deane F; Wilkerson, Emily M; Turton, Keren B et al. (2017) Proteomics of Eosinophil Activation. Front Med (Lausanne) 4:159
Hope, Chelsea; Emmerich, Philip B; Papadas, Athanasios et al. (2017) Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. J Immunol 199:1933-1941

Showing the most recent 10 out of 95 publications