Pediatric cardiology remains a field with relatively few researchers, basic or clinical. The reasons for this are complex and may relate to trends affecting many pediatric subspecialities. Nevertheless, the Children's Hospital of Philadelphia (CHOP) cardiology research programs overall have continued to demonstrate outstanding growth, offering a broad array of research training opportunities for the postdoctoral fellows in this Program. We seek to train physicians and basic scientists in molecular therapeutics for heart disease in children. It is our expectation that our trainees will become creative cutting edge researchers whose efforts will lead to new therapies and diagnostic techniques for pediatric cardiology. Our working definition of molecular therapy has now been broadened to enable this goal and includes training opportunities in four major areas: I) Experimental pharmacology and gene therapy; II) Molecular genetics and development; III) Cardiovascular pathophysiology, IV) Imaging, outcomes, clinical pharmacology, and clinical epidemiology. There has been enthusiastic interest in this T32 program from its inception including a strong minority recruitment. An outstanding cohort of productive trainees has already graduated from our Program. The composition of our proposed trainee group for the Program renewal is planned to include 4 physicians, who will be recruited from our pediatric cardiology fellowship, and 3 Ph.D. scientists or non-pediatric cardiology physician scientists. We have increased by one the number of physicians because of the increase in interest among our cardiology fellows at CHOP.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007915-08
Application #
7031750
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Commarato, Michael
Project Start
1999-07-01
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
8
Fiscal Year
2006
Total Cost
$371,843
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chang, J C; Knight, A M; Xiao, R et al. (2018) Use of echocardiography at diagnosis and detection of acute cardiac disease in youth with systemic lupus erythematosus. Lupus 27:1348-1357
O'Byrne, Michael L; McBride, Michael G; Paridon, Stephen et al. (2018) Association of Habitual Activity and Body Mass Index in Survivors of Congenital Heart Surgery: A Study of Children and Adolescents With Tetralogy of Fallot, Transposition of the Great Arteries, and Fontan Palliation. World J Pediatr Congenit Heart Surg 9:177-184
Avitabile, Catherine M; Goldberg, David J; Leonard, Mary B et al. (2018) Leg lean mass correlates with exercise systemic output in young Fontan patients. Heart 104:680-684
Zacharias, William J; Frank, David B; Zepp, Jarod A et al. (2018) Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555:251-255
DiLorenzo, Michael P; Elci, Okan U; Wang, Yan et al. (2018) Longitudinal Changes in Right Ventricular Function in Tetralogy of Fallot in the Initial Years after Surgical Repair. J Am Soc Echocardiogr 31:816-821
Mohan, Shaun; Nandi, Deipanjan; Stephens, Paul et al. (2018) Implementation of a Clinical Pathway for Chest Pain in a Pediatric Emergency Department. Pediatr Emerg Care 34:778-782
Chang, Joyce C; Mandell, David S; Knight, Andrea M (2018) High Health Care Utilization Preceding Diagnosis of Systemic Lupus Erythematosus in Youth. Arthritis Care Res (Hoboken) 70:1303-1311
Lynch, Jennifer M; Ko, Tiffany; Busch, David R et al. (2018) Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease. J Thorac Cardiovasc Surg 156:1657-1664
DiLorenzo, Michael P; Goldmuntz, Elizabeth; Nicolson, Susan C et al. (2018) Early postoperative remodelling following repair of tetralogy of Fallot utilising unsedated cardiac magnetic resonance: a pilot study. Cardiol Young 28:697-701
Pan, Daniel C; Myerson, Jacob W; Brenner, Jacob S et al. (2018) Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells. Sci Rep 8:1615

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