Training in Molecular Therapeutics for Pediatric Cardiology (TMTPC): Pediatric cardiology is a relatively small specialty with fewer than 2000 board certified specialists, and nationwide, at this time there is a small core group of laboratory and clinical researchers in this field. Nevertheless, pediatric cardiology is a requisite component of every major academic medical center, because of the relative high frequency and acuity of severe congenital heart disease early in life. With advances in genetics, imaging, pharmacology and surgical outcomes, the field of pediatric cardiology is now rich with research career development opportunities for trainees. Thus, the goal of this program is to address the as yet unmet need for more committed researchers in the field of pediatric cardiovascular disease. TMTPC program direction, aims and objectives: Program leadership will continue be provided by Dr. Robert Levy, continuing as contact PI, with responsibilities focused on laboratory research trainees. Dr. Robert Shaddy will become a 2nd PI with leadership responsibilities focused on the clinical research trainees. Dr. Shaddy is the Division Chief in Cardiology at CHOP, Vice Chair of the Department of Pediatrics at Penn, Director of CHOP's Pediatric Heart Network (PHN)-NHBLI program, and an experienced clinical researcher.
The aims of the TMTPC are to: """""""" Identify, recruit and foster research trainees, both CHOP cardiology fellows and other scientists willing to commit to training and career development in the field of pediatric cardiovascular research """""""" Match up trainees strengths and interests with mentoring teams """""""" Provide guidance for structured learning opportunities """""""" Maximize the opportunities for mentored research and career mentoring The objectives of the TMTPC are to: """""""" Train a cadre of committed researchers to advance the field of pediatric cardiovascular research. """""""" Provide these individuals with the skill sets and foundation for career advancement """""""" Encourage leadership and innovation TMTPC Goals-to pursue the aims and objectives through a training program consisting of: """""""" Didactic opportunities, including core requirements and courses designed to provide research skills """""""" Seminars, workshops and a journal club focusing on research and progress in the field """""""" Mentoring with a team approach, mentor training and scholarship oversight """""""" Programmatic interactions with mainstream research through the NHBLI PHN.

Public Health Relevance

Congenital heart disease remains a major problem in the United States, as one of the leading causes of morbidity and mortality in children. The proposed program will train researchers in this field, whose goal will be to improve outcomes for children with cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007915-16
Application #
8607329
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Scott, Jane
Project Start
1999-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Pan, Daniel C; Myerson, Jacob W; Brenner, Jacob S et al. (2018) Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells. Sci Rep 8:1615
Chang, J C; Xiao, R; Mercer-Rosa, L et al. (2018) Child-onset systemic lupus erythematosus is associated with a higher incidence of myopericardial manifestations compared to adult-onset disease. Lupus 27:2146-2154
Driesbaugh, Kathryn H; Branchetti, Emanuela; Grau, Juan B et al. (2018) Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation. J Mol Cell Cardiol 115:94-103
Nandi, Deipanjan; Miller, Kelley D; Bober, Carley M et al. (2018) Systemic Atrioventricular Valve Excision and Ventricular Assist Devices in Pediatric Patients. Ann Thorac Surg 105:170-174
Battig, Mark R; Fishbein, Ilia; Levy, Robert J et al. (2018) Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Deliv Transl Res 8:954-963
Geanacopoulos, Alexandra T; Savla, Jill J; Pogoriler, Jennifer et al. (2018) Bronchoscopic and histologic findings during lymphatic intervention for plastic bronchitis. Pediatr Pulmonol 53:1574-1581
DiLorenzo, Michael; Hwang, Wei-Ting; Goldmuntz, Elizabeth et al. (2018) Diastolic dysfunction in tetralogy of Fallot: Comparison of echocardiography with catheterization. Echocardiography 35:1641-1648
Mercer-Rosa, Laura; Zhang, Xuemei; Tanel, Ronn E et al. (2018) Perioperative Factors Influence the Long-Term Outcomes of Children and Adolescents with Repaired Tetralogy of Fallot. Pediatr Cardiol :
Chang, J C; Knight, A M; Xiao, R et al. (2018) Use of echocardiography at diagnosis and detection of acute cardiac disease in youth with systemic lupus erythematosus. Lupus 27:1348-1357
O'Byrne, Michael L; McBride, Michael G; Paridon, Stephen et al. (2018) Association of Habitual Activity and Body Mass Index in Survivors of Congenital Heart Surgery: A Study of Children and Adolescents With Tetralogy of Fallot, Transposition of the Great Arteries, and Fontan Palliation. World J Pediatr Congenit Heart Surg 9:177-184

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