? ? This training grant in hemostasis, thrombosis, and vascular biology is entering its first competitive renewal. These areas of research targeted for continued support under this T32 have continued to undergo rapid and exciting advances in the basic research arena and have begun to see the translation of these findings to the care of patients with various cardiovascular diseases. We believe that the combined University of Pennsylvania and Children's Hospital of Philadelphia campuses offer a very rich resource of outstanding researchers in these areas from multiple different Departments and even Institutions. While a number of these investigators have been highly interactive over the years, we believed that there was a need to have an over-riding super-structure to bring together these outstanding, but scattered resources on the two campuses, when first submitted five years ago, this training grant was part of that effort. It was aimed at drawing together investigators to provide cohesive and attractive training to pre- and post-doctoral fellows to attract and retain the best trainees into these fields of endeavors. We believe that through this grant we have begun to organize our presence on campus much like the PENN Cancer Center. We have provided several organized courses and seminars in our areas of cardiovascular research that together with our yearly daylong outside review of all our trainees have provided that first wave of trainees with an organized mentored experience, a deeper understanding of the areas of hemostasis, thrombosis, and vascular biology and better opportunities to advance their career. Over the coming 5 years, we intend to further increase the didactic training component in hemostasis and thrombosis in this T32, and to continue to pursue and persuade the best of our trainees to remain in the cardiovascular field. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007971-08
Application #
7465339
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Sarkar, Rita
Project Start
2001-07-01
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$546,336
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Li, Xinzhi; Mazaleuskaya, Liudmila L; Ballantyne, Laurel L et al. (2018) Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice. J Lipid Res 59:102-112
Pishko, Allyson M; Fardin, Sara; Lefler, Daniel S et al. (2018) Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia. Blood Adv 2:3155-3162
Li, Xinzhi; Mazaleuskaya, Liudmila L; Yuan, Chong et al. (2018) Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions. J Lipid Res 59:89-101
Pan, Daniel C; Myerson, Jacob W; Brenner, Jacob S et al. (2018) Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells. Sci Rep 8:1615
Mazaleuskaya, Liudmila L; Salamatipour, Ashkan; Sarantopoulou, Dimitra et al. (2018) Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575
Kiseleva, Raisa Yu; Glassman, Patrick M; Greineder, Colin F et al. (2018) Targeting therapeutics to endothelium: are we there yet? Drug Deliv Transl Res 8:883-902
Kiseleva, Raisa Yu; Greineder, C F; Villa, C H et al. (2018) Vascular endothelial effects of collaborative binding to platelet/endothelial cell adhesion molecule-1 (PECAM-1). Sci Rep 8:1510
Greineder, Colin F; Johnston, Ian H; Villa, Carlos H et al. (2017) ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Adv 1:1452-1465
Hanby, Hayley A; Bao, Jialing; Noh, Ji-Yoon et al. (2017) Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. Blood Adv 1:1478-1490
Pishko, Allyson M; Cuker, Adam (2017) Heparin-Induced Thrombocytopenia in Cardiac Surgery Patients. Semin Thromb Hemost 43:691-698

Showing the most recent 10 out of 100 publications