We propose to establish an NIH-supported research training program in Immunohematology and Transfusion Medicine designed to take MDs and MD/PhDs, who have fully completed their clinical training in these disciplines, and provide them with the tools to become productive physician-scientists with an abiding interest in basic science and translational research in these relatively underrepresented investigative areas. We believe that these biomedical scientists should be trained in an environment that emphasizes basic biological processes and which simultaneously provides continuous didactic exposure to those state-of-the-art investigative issues which are relatively unique to immunohernatology and transfusion medicine, e.g., transfusion-induced immunomodulation, cellular alteration and apoptosis during ex vivo storage, cell engineering pretransfusion, and allo- and auto- immunity to circulating cells and plasma proteins. Our interdisciplinary and multi-departmental faculty include 21 investigators (19 senior and 2 junior, including MDs, MD/PhDs and PhDs) who have a long history of collaborative publications, trainees and grants and whose laboratories are very experienced in the simultaneous training of post-doctoral PhDs, post doctoral MDs and pre-doctoral PhD candidates. We have the educational philosophy that trainees in this program must have their core experience at the bench, that they require carefully crafted training and career guidance by an individualized trainee committee somewhat analogous to a pre-doctoral thesis committee, and that we must provide ongoing venues for them to interact on a one-to-one basis with additional internationally recognized investigator's in immunohematology and transfusion who are from other institutions. In the 1st year of the grant we are requesting support for one post-doctoral position and thereafter for support of 2 post-doctoral positions each year. We expect that MD trainees will require 2-3 years of training at this level before moving to a K-award equivalent and MD/PhDs 1-2 years with one new trainee added to the program each year. We have had past successful experience training exactly the same type of individuals we propose for this T32 but using mechanisms of support other than a T32 (individual NRSAs, research fellowships from foundations and the like). Those individuals have all gone on to successful academic careers. We believe strongly that an institutional T32 would provide a markedly enhanced, coordinated and formalized training experience for this type of clinician-scientist and provide a smoother pathway for these individuals to move to the next level of independence and eventually comprise the next generation of clinician-scientists who can bridge the gap between fundamental research and clinical need in immunohematology and transfusion.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007974-02
Application #
6490649
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Mondoro, Traci
Project Start
2001-08-01
Project End
2006-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$113,527
Indirect Cost
Name
Yale University
Department
Pathology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hauser, Ronald George; Quine, Douglas B; Ryder, Alex (2018) LabRS: A Rosetta stone for retrospective standardization of clinical laboratory test results. J Am Med Inform Assoc 25:121-126
Zhang, Feng; Zarkada, Georgia; Han, Jinah et al. (2018) Lacteal junction zippering protects against diet-induced obesity. Science 361:599-603
Hauser, Ronald G; Quine, Douglas B; Ryder, Alex et al. (2018) Unit conversions between LOINC codes. J Am Med Inform Assoc 25:192-196
Juchem, Kathryn W; Sacirbegovic, Faruk; Zhang, Cuiling et al. (2018) PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease. J Immunol 200:834-846
Heinolainen, Krista; Karaman, Sinem; D'Amico, Gabriela et al. (2017) VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling. Circ Res 120:1414-1425
Rausch, Manuel K; Genet, Martin; Humphrey, Jay D (2017) An augmented iterative method for identifying a stress-free reference configuration in image-based biomechanical modeling. J Biomech 58:227-231
Gibb, David R; Liu, Jingchun; Santhanakrishnan, Manjula et al. (2017) B cells require Type 1 interferon to produce alloantibodies to transfused KEL-expressing red blood cells in mice. Transfusion 57:2595-2608
Natarajan, Prabitha; Liu, Dong; Patel, Seema R et al. (2017) CD4 Depletion or CD40L Blockade Results in Antigen-Specific Tolerance in a Red Blood Cell Alloimmunization Model. Front Immunol 8:907
Albright, Benjamin; Dhaher, Roni; Wang, Helen et al. (2017) Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. Exp Neurol 288:122-133
Rausch, Manuel K; Zöllner, Alexander M; Genet, Martin et al. (2017) A virtual sizing tool for mitral valve annuloplasty. Int J Numer Method Biomed Eng 33:

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