The overall objective of the cardiovascular disease (CVD) epidemiology and prevention postdoctoral training program at Northwestern University is to prepare academically-oriented MD and PhD trained investigators from diverse scientific and racial/ethnic backgrounds for research-intensive careers in CVD epidemiology and prevention. This ongoing multi-disciplinary research training program (now in Year 14) proposes to continue supporting 4 postdoctoral trainees for a training period that is typically 2 years in duration. At the completion of training, our alumni will be prepared for independent research careers in many sectors including academia, government, public or private industry. We will achieve this outcome by providing training in epidemiology, prevention, biostatistics, nutrition, behavioral medicine, vascular medicine, endocrinology, cardiovascular imaging, health services research, dissemination and implementation, applied genetics, transcriptomics, proteomics and metabolomics. Mentored research experiences are complemented by coursework chosen as needed individually for each trainee. Growth in knowledge, skills, attitudes and behaviors is guided by an individual development plan (IDP) prepared by each trainee and reviewed regularly with the mentoring team comprised of at least 2 highly experienced mentors. The centerpiece of the training program remains the completion of mentored research projects that yield scientific products (e.g., publications) in any of the above areas. The home for the training program remains a resource-rich environment that is home to multiple large- scale CVD cohort studies that permit immediate scientific productivity. Three primary innovations for this training period include: 1) an expansion of our program focus from traditional epidemiologic and biostatistical cohort studies and designs to address contemporary challenges in cardiovascular health; 2) the implementation of competency-based training curriculum; and, 3) an expanded approach to evaluating program outcomes. Trainees are drawn from clinical backgrounds (primarily MD intending to pursue a physician/scientist career in cardiovascular medicine and preventive cardiology) and research backgrounds (PhD in biostatistics, epidemiology, nutrition, or other related fields). We intend to continue our successful active approaches to recruiting and retaining underrepresented minority investigators. The Program Director, Associate Director, and mentors are a highly experienced group that has worked together for many years which will help to assure coordinated training. The Directors are supported by an administrative infrastructure that provides input on the program vision and mission, selection of trainees and curriculum. Ongoing evaluation allows for programmatic modifications in order to maximize the effectiveness of the program. Using these approaches, we expect to continue our success in response to the NHLBI call to establish ?a diverse scientific workforce equipped with the relevant skills, knowledge and resources to tackle future HLBS [Heart, Lung, Blood and Sleep] challenges.?

Public Health Relevance

The objective of this renewal application is to prepare 4 academically-oriented MD and PhD-trained investigators for research-intensive careers in cardiovascular disease (CVD) epidemiology and prevention. We will accomplish this over a 2-year training period through a combination of mentored research activities, coursework and seminars/workshops led by accomplished senior researchers at Northwestern University.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Coady, Sean
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Northwestern University at Chicago
Public Health & Prev Medicine
Schools of Medicine
United States
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Mayne, Stephanie L; Gordon-Larsen, Penny; Schreiner, Pamela J et al. (2018) Longitudinal Associations of Cigarette Prices with Smoking Cessation: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Nicotine Tob Res :
Mayne, Stephanie L; Moore, Kari A; Powell-Wiley, Tiffany M et al. (2018) Longitudinal Associations of Neighborhood Crime and Perceived Safety With Blood Pressure: The Multi-Ethnic Study of Atherosclerosis (MESA). Am J Hypertens 31:1024-1032
Bancks, Michael P; Carnethon, Mercedes R; Jacobs Jr, David R et al. (2018) Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes Care 41:2579-2585
Mayne, Stephanie L; Yellayi, Disha; Pool, Lindsay R et al. (2018) Racial Residential Segregation and Hypertensive Disorder of Pregnancy Among Women in Chicago: Analysis of Electronic Health Record Data. Am J Hypertens 31:1221-1227
Bundy, Joshua D; Mills, Katherine T; Chen, Jing et al. (2018) Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National Data. JAMA Cardiol 3:572-581
Mutharasan, R Kannan; Ahmad, Faraz S; Gurvich, Itai et al. (2018) Buffer or Suffer: Redesigning Heart Failure Postdischarge Clinic Using Queuing Theory. Circ Cardiovasc Qual Outcomes 11:e004351
Mayne, Stephanie L; Widome, Rachel; Carroll, Allison J et al. (2018) Longitudinal Associations of Smoke-Free Policies and Incident Cardiovascular Disease. Circulation 138:557-566
Reis, Jared P; Allen, Norrina B; Bancks, Michael P et al. (2018) Duration of Diabetes and Prediabetes During Adulthood and Subclinical Atherosclerosis and Cardiac Dysfunction in Middle Age: The CARDIA Study. Diabetes Care 41:731-738
Patel, Ravi B; Vaduganathan, Muthiah; Bhatt, Deepak L et al. (2018) Characterizing High-Performing Articles by Altmetric Score in Major Cardiovascular Journals. JAMA Cardiol :
Akhabue, Ehimare; Perak, Amanda M; Chan, Cheeling et al. (2018) Racial Differences in Rates of Change of Childhood Body Mass Index and Blood Pressure Percentiles. J Pediatr 202:98-105.e6

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