The Department of Bioengineering, University of Pittsburgh (UOP) is seeking continued support for a predoctoral training program (8 positions/year) aimed at educating talented students from engineering and other quantitative sciences for careers in biomedical research in the cardiovascular area. UOP has been at the forefront of education and research in this field, with two key components contributing to this status. First, a mechanism is in place whereby our students are exposed first-hand to actual clinical problems requiring bioengineering input for their solution within various medical disciplines (e.g., cardiology, cardio-thoracic surgery, vascular surgery, radiology). Second, there has been, and continues to be, a significant Institutional commitment to these research and educational endeavors. The proposed program is interdisciplinary and interdepartmental in nature. Although the Department of Bioengineering forms the core, the training faculty is drawn from a number of departments: Chemical Engineering, Cell Biology &Physiology, Medicine (Cardiology), Critical Care Medicine, Pediatrics (Cardiology), and Surgery (Vascular). The participating faculty members are (bio) engineers, physiologists, biophysicist, cell and molecular biologists, adult and pediatric cardiologists, and critical care specialists, with vigorous and well-funded research programs. There are three focus areas of this program: (1) Basic understanding and quantitative characterization of native (normal and pathological conditions) and perturbed (i.e., with deployment of man-made devices or constructs) cardiovascular function at various levels of organization (cell, tissue, whole organ), (2) Imaging for functional assessment at various levels of organization (cell, tissue, whole organ), and (3) Design and optimization of artificial devices and constructs (mechanical, tissue-engineered, and hybrid). Students are drawn mainly from engineering schools, although they may also come from biology, physics, chemistry, and mathematics. Program coursework (12 didactic courses and several workshops) is designed to provide both breadth and depth in engineering and biological sciences and also includes a formal exposure to biostatistics, bioethics, and professional and career development issues. A novel aspect of the program is that students are required to formally participate in a clinical experience (Clinical Internship and Rotation). Thus, the training program provides a unique educational and research experience with respect to basic and applied cardiovascular engineering and sciences. Finally, each student receives extensive research training in the laboratories of the training faculty. Seventeen predoctoral trainees have participated in the program during the current (first) cycle and we believe that the trainee performance and program outcomes have been outstanding (see Progress Report).
Cardiovascular diseases are leading causes of death and disability in the Western world. Historical observations suggest that revolutionary scientific and therapeutic advances often emerge at the interface between disciplines. Therefore, we believe that individuals trained in both engineering principles and cardiovascular science (biology) are critically needed to develop novel therapeutic approaches for treating cardiovascular diseases. The proposed program aims to provide such training to students pursuing a doctoral degree in bioengineering.
|D'Amore, Antonio; Luketich, Samuel K; Raffa, Giuseppe M et al. (2018) Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure. Biomaterials 150:25-37|
|May, Alexandra G; Jeffries, R Garrett; Frankowski, Brian J et al. (2018) Bench Validation of a Compact Low-Flow CO2 Removal Device. Intensive Care Med Exp 6:34|
|Olia, Salim E; Wearden, Peter D; Maul, Timothy M et al. (2018) Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device. J Thorac Cardiovasc Surg 156:1643-1651.e7|
|Gau, David; Lewis, Taber; McDermott, Lee et al. (2018) Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction. J Biol Chem 293:2606-2616|
|Orizondo, Ryan A; May, Alexandra G; Madhani, Shalv P et al. (2018) In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung. ASAIO J 64:806-811|
|Hussey, George S; Cramer, Madeline C; Badylak, Stephen F (2018) Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue. Cell Mol Gastroenterol Hepatol 5:1-13|
|Malkin, Alexander D; Ye, Sang-Ho; Lee, Evan J et al. (2018) Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices. J Biomed Mater Res B Appl Biomater 106:2681-2692|
|Joy, Marion; Gau, David; Castellucci, Nevin et al. (2017) The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. J Biol Chem 292:11777-11791|
|Amdahl, Matthew B; DeMartino, Anthony W; Tejero, Jesús et al. (2017) Cytoglobin at the Crossroads of Vascular Remodeling. Arterioscler Thromb Vasc Biol 37:1803-1805|
|Nguyen, Man M; Ding, Xuan; Leers, Steven A et al. (2017) Multi-Focus Beamforming for Thermal Strain Imaging Using a Single Ultrasound Linear Array Transducer. Ultrasound Med Biol 43:1263-1274|
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