This is a proposal for the competing continuation of the University of Pittsburgh T32 Training Program in Cardiovascular Epidemiology funded by NHLBI since 2008. Cardiovascular disease (CVD) remains the leading cause of death despite a more than 50% decline in age-adjusted mortality from CVD in the past five decades. This Training Program thus addresses the critical need to promote epidemiological research of CVD. The primary goal of our T32 Program is to train individuals in cardiovascular epidemiology based on a pathophysiological understanding and experiential learning to thereby help develop in the future better prevention strategies. Our philosophy is to provide a core foundation of didactic training in epidemiology focusing on subclinical atherosclerosis, CVD biomarkers and outcomes with strong methodological skills, customized to the experience and background of each trainee. The Training Program is organized around three Research Cores: 1) subclinical atherosclerosis, 2) biostatistics/ epidemiological methods and 3) cardiology, grounded in six areas of strength ((i) vascular aging, (ii) women's health, (iii) high risk & international populations, (iv) nutrition & environment, (v) physical activity and (vi) psychosocial factors). To address challenges and opportunities which epidemiological research faces, our Training Program is updated by introducing Big Data, Mobile Health and Cross-Cohort Collaboration components for which we have rich faculty expertise. Doing so will position our trainees to be independent cardiovascular epidemiologists in multidisciplinary research settings competent in traditional and novel epidemiological methods in CVD. Trainees will have a primary mentor, work closely with other faculty members and a peer mentor who is a more experienced trainee. The Training Program consists of course work, research field work and professional development, all individually tailored to each trainee. Research field work includes data collection/management and data analysis. Professional development includes an independent research project, a remote training experience, grant writing experience, manuscript preparation, participation in national conferences, skill development workshops and training in the Responsible Conduct of Research. The Training Program is designed to produce investigators skilled in a multidisciplinary approach to research in cardiovascular epidemiology, who are comfortable with using subclinical atherosclerosis, CVD biomarkers or outcomes data in cross-discipline collaborations. The Training Program will continue to include 4 pre-doctoral and 2 post- doctoral positions in epidemiology.

Public Health Relevance

Cardiovascular disease (CVD) remains the leading cause of death in the US. This Training Program thus addresses a critical need to train individuals in cardiovascular epidemiology, ultimately to better prevent CVD. Our Training Program reflects the changing needs of our trainees in research in cardiovascular epidemiology and aims to produce independent cardiovascular epidemiologists in multidisciplinary research settings competent in traditional as well as novel epidemiological methods in CVD.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Coady, Sean
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University of Pittsburgh
Public Health & Prev Medicine
Schools of Public Health
United States
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Niemczyk, Nancy Anderson; Catov, Janet M; Desai, Mansi M et al. (2018) Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output. Hypertens Pregnancy 37:204-211
Jorgensen, Dana R; Shaaban, C Elizabeth; Wiley, Clayton A et al. (2018) A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review. Am J Physiol Heart Circ Physiol 314:H1117-H1136
Jorgensen, Dana; White, Gretchen E; Sekikawa, Akira et al. (2018) Higher dietary inflammation is associated with increased odds of depression independent of Framingham Risk Score in the National Health and Nutrition Examination Survey. Nutr Res 54:23-32
Jonassaint, Charles R; Birenboim, Amit; Jorgensen, Dana Rae et al. (2018) The association of smartphone-based activity space measures with cognitive functioning and pain sickle cell disease. Br J Haematol 181:395-397
Niemczyk, Nancy Anderson; Bertolet, Marianne; Catov, Janet M et al. (2018) Common carotid artery intima-media thickness increases throughout the pregnancy cycle: a prospective cohort study. BMC Pregnancy Childbirth 18:195
Egnot, Natalie Suder; Barinas-Mitchell, Emma; Criqui, Michael H et al. (2018) An exploratory factor analysis of inflammatory and coagulation markers associated with femoral artery atherosclerosis in the San Diego Population Study. Thromb Res 164:9-14
Genuardi, Michael V; Althouse, Andrew D; Sharbaugh, Michael S et al. (2018) Exploring the mechanisms of the racial disparity in drowsy driving. Sleep Health 4:331-338
Shaaban, C E; Aizenstein, H J; Jorgensen, D R et al. (2017) In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T. AJNR Am J Neuroradiol 38:1923-1928
Jorgensen, Dana R; Metti, Andrea; Butters, Meryl A et al. (2017) Disease severity and slower psychomotor speed in adults with sickle cell disease. Blood Adv 1:1790-1795
Cort├ęs, Yamnia I; Reame, Nancy; Zeana, Cosmina et al. (2017) Cardiovascular Risk in HIV-Infected and Uninfected Postmenopausal Minority Women: Use of the Framingham Risk Score. J Womens Health (Larchmt) 26:241-248

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