This renewal application is to continue supporting our successful Pulmonary Genetic Medicine Training Program for postdoctoral fellows at Weill Cornell Medical College (WCMC) that will complete its first five-year period of funding by NHLBI August 31, 2014. The Pulmonary Genetic Medicine Training Program is an inter-departmental and inter-institutional collaborative effort with a faculty of experienced investigators at WCMC and Memorial Sloan-Kettering Cancer Center (MSKCC). The goal of the Training Program is still to provide MD, PhD and MD/PhD trainees interested in pulmonary biology and medicine with a multi-disciplinary training in genomics and gene expression, gene therapy, stem cells, metabolomics, statistical genetics and computational science, epidemiology, ethics and regulatory affairs. The Training Program will continue to support 6 postdoctoral trainees, each for up to 3 years. Under the direction of Ronald G. Crystal, Professor and Chairman of the Department of Genetic Medicine, the Program has grown and currently incorporates 26 faculty members. Dr. Crystal will continue to be assisted by 4 Associate Directors, an internal Executive Committee, a Committee on Recruitment and Retention, and an External Advisory Committee. In addition, Fernando Martinez, Professor of Medicine, will be Deputy Director to assist Dr. Crystal in management of the program. In the past 5 years, we have recruited 12 trainees for 6 postdoctoral slots. To date, the 12 trainees have published 45 peer-reviewed papers including 17 first-authored. They all had the opportunity to present their research (28 first-author abstracts) at national and international conferences. Of the 12 trainees, 4 have gone on to junior faculty positions, 2 have gone back to finish clinical training and 6 have continued in post-doctoral training. Of the 4 at the faculty level, 1 successfully obtained a grant from the National Foundation for Cancer Research, 1 has applied for a NIH Mentored Research Scientist Development Award (K01) and 2 are currently working on a grant submission to the NIH. Among the 12 trainees, 1 was from an underrepresented minority of Hispanic origin, now a faculty member, 3 are of Asian ancestry and 6 are women. Besides the existing educational opportunities that were in place at WCMC and MSKCC at the time of the first cycle submission, we instituted a highly successful Pulmonary Genetic Medicine Didactic Course created for our trainees, open for the entire WCMC and MSKCC communities. This renewal proposal seeks continued support for the growth of the Pulmonary Genetic Medicine Training Program.
. The focus of the Weill Cornell Pulmonary Genetic Medicine Training Program is to train MD, MD/PhD and PhD post-doctoral fellows to perform research that provides an understanding of the relationship between the genome, the environment and the risk for pulmonary disease. The ulti- mate goal is to translate that knowledge into future personalized, genetic medicine therapies for lung diseases.
| Zuo, Wu-Lin; Shenoy, Sushila A; Li, Sheng et al. (2018) Ontogeny and Biology of Human Small Airway Epithelial Club Cells. Am J Respir Crit Care Med 198:1375-1388 |
| O'Beirne, Sarah L; Shenoy, Sushila A; Salit, Jacqueline et al. (2018) Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome. Am J Respir Crit Care Med 198:1413-1422 |
| Schachterle, William; Badwe, Chaitanya R; Palikuqi, Brisa et al. (2017) Sox17 drives functional engraftment of endothelium converted from non-vascular cells. Nat Commun 8:13963 |
| Hicks, Martin J; Chiuchiolo, Maria J; Ballon, Douglas et al. (2016) Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma. PLoS One 11:e0162978 |
| Zhou, Haixia; Brekman, Angelika; Zuo, Wu-Lin et al. (2016) POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. J Immunol 196:3159-67 |
| Evans, Suzette M; Foltin, Richard W; Hicks, Martin J et al. (2016) Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques. Pharmacol Biochem Behav 150-151:76-86 |
| Fakhro, Khalid A; Yousri, Noha A; Rodriguez-Flores, Juan L et al. (2015) Copy number variations in the genome of the Qatari population. BMC Genomics 16:834 |
| Hicks, Martin J; Funato, Kosuke; Wang, Lan et al. (2015) Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma. Cancer Gene Ther 22:1-8 |
| Ginsberg, Michael; Schachterle, William; Shido, Koji et al. (2015) Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Nat Protoc 10:1975-85 |
| 1000 Genomes Project Consortium; Auton, Adam; Brooks, Lisa D et al. (2015) A global reference for human genetic variation. Nature 526:68-74 |
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