This application is a submission for the second renewal of the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) entitled ?Vascular Surgery Scientist Training Program? (VSSTP). The objective of the VSSTP at Northwestern University Feinberg School of Medicine is to increase the number of vascular surgeon-scientists dedicated to careers in improving the quality of life of patients with vascular disease. The VSSTP was established in 2009 with the goal of training these potential vascular surgeon-scientists interested in pursuing a career dedicated to studying vascular disease? arterial, venous, and lymphatic disorders?by providing a training experience with mentors from a wide range of specialties. Cardiovascular research has historically been heavily focused on heart disease; thus, peripheral vascular disease (PVD) afflicting the arterial, venous, and lymphatic circulations is consistently under- diagnosed, under-treated, and under-studied. The genesis and evolution of the VSSTP has been to change this pattern and provide a focused mentorship experience dedicated to enhancing the study of PVD. The goal of the VSSTP is to recruit two MD/DO trainees per year for two years of training for a total of 10 trainees for this second renewal. Candidates will have at least two years of surgical residency training. The program is arranged around three important constructs: 1) vascular biology research, basic science investigations of the biology of the peripheral vascular system; 2) biomedical engineering investigations, research into developing new devices and mechanisms to treat vascular disease; and 3) clinical outcomes/health services research with respect to vascular surgery and delivery of care. Trainees may select a focused mentored research experience within one of these domains upon which an independent learning plan and contract are established mutually between the trainee and the primary mentor. The clinical outcomes/health services research track provides the opportunity to pursue a Master of Science in Health Services and Outcomes Research degree. An innovative guidance plan to provide mentoring and coaching to the trainees throughout their training and early career is intended to help the trainee find an academic position that supports research to encourage their success and productivity as a young surgeon-scientist. There are 21 dedicated mentors from 10 departments, providing a wide range of possible training experiences to the trainees. Mentors are selected based on their expertise in their chosen fields of research as well as their track record of mentoring. Built into the program is the mechanism to help younger mentors to improve their mentoring skills.

Public Health Relevance

Peripheral vascular disease (PVD) encompasses disorders of the arterial, venous, and lymphatic circulations, but is notoriously under-diagnosed, under-treated, and under-studied. With the expanding geriatric population and the obesity and diabetic epidemics in this country, there has been an exponential increase in the number of patients suffering from PVD, many of whom require surgery or an endovascular procedure despite advances in the medical treatment of PVD. The objective of the VSSTP at Northwestern University Feinberg School of Medicine is to increase the number of vascular surgeon-scientists dedicated to careers in improving the quality of life of patients with PVD.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094293-12
Application #
9914880
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Huang, Li-Shin
Project Start
2009-05-01
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
12
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Mansukhani, Neel A; Miller, Kyle R; Havelka, George E et al. (2018) Aorta-innominate bypass through ministernotomy. J Vasc Surg 68:607-610
Gregory, Elaine K; Webb, Antonio; Vercammen, Janet M et al. (2018) Inhibiting intimal hyperplasia in prosthetic vascular grafts via immobilized all-trans retinoic acid. J Control Release 274:69-80
Nooromid, Michael J; Mansukhani, Neel A; Deschner, Benjamin W et al. (2018) Surgical interns: Preparedness for opioid prescribing before and after a training intervention. Am J Surg 215:238-242
Morgan, Courtney E; Mansukhani, Neel A; Eskandari, Mark K et al. (2018) Ten-year review of isolated spontaneous mesenteric arterial dissections. J Vasc Surg 67:1134-1142
Mansukhani, Neel A; Hekman, Katherine E; Yoon, Dustin Y et al. (2018) Impact of Body Mass Index on Outcomes after Mesenteric Revascularization for Chronic Mesenteric Ischemia. Ann Vasc Surg 48:159-165
Cason, Cori A; Dolan, Kyle T; Sharma, Gaurav et al. (2018) Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J Vasc Surg 68:1552-1562.e7
Zamor, Kimberly C; Hoel, Andrew W; Helenowski, Irene B et al. (2018) Comparison of Direct and Less Invasive Techniques for the Treatment of Severe Aorto-Iliac Occlusive Disease. Ann Vasc Surg 46:226-233
Chen, Edmund B; Cason, Cori; Gilbert, Jack A et al. (2018) Current State of Knowledge on Implications of Gut Microbiome for Surgical Conditions. J Gastrointest Surg 22:1112-1123
Nooromid, Michael J; Blay Jr, Eddie; Holl, Jane L et al. (2018) Discharge prescription patterns of opioid and nonopioid analgesics after common surgical procedures. Pain Rep 3:e637
Bell, Jonathan B; Rink, Jonathan S; Eckerdt, Frank et al. (2018) HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma. Sci Rep 8:1211

Showing the most recent 10 out of 56 publications