Acute and chronic lung diseases are major causes of morbidity and mortality throughout the world. For many of these diseases, the fundamental pathobiology is not well understood and effective disease-modifying treatments are not available. This training program titled ?Interdisciplinary Training Program in Lung Research? focuses on training researchers in basic mechanisms of lung disease and is committed to equipping young investigators with the skill set necessary to develop into successful researchers and academic leaders. The Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University and the Vanderbilt Center for Lung Research (VCLR) have a long, successful history in developing well-trained researchers who have the vision and the skills with which to embark on successful research careers. This program is housed in the VCLR, which was developed to coordinate and enhance collaborative interdisciplinary research and training. Dr. Timothy Blackwell (director of the VCLR) serves as program director. The program is designed to support post-doctoral trainees (both M.D. and Ph.D.) who show exceptional aptitude for successfully pursuing an academic research career. Trainees concentrate on one of five disease focused areas of existing expertise in the VCLR: acute lung injury and host defense, asthma and airway disease, interstitial lung disease, pulmonary hypertension, or lung cancer. A customized mentoring team is formed for each trainee, consisting of a mentor with nationally recognized expertise in the area and a research advisory committee to provide additional guidance, mentoring, and feedback. The trainee's experience is enhanced by interactions with other investigators and trainees in existing lung disease-focused research programs in the VCLR, an extensive program of seminars and conferences, and coursework tailored to meet the needs of each trainee. As a result, each trainee develops an understanding of the translational paradigm in his/her area of research and attains the academic skills necessary to become a future leader in the field of lung research.

Public Health Relevance

While there are unprecedented opportunities for advancement in understanding of the fundamental mechanisms of lung diseases, the pipeline of new investigators who are trained and committed to careers in lung disease-oriented biomedical research is inadequate. This interdisciplinary training program is designed to meet this challenge by preparing future leaders in lung research to advance science and improve health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL094296-11
Application #
9417632
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Kalantari, Roya
Project Start
2008-07-01
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Brown, Kyle L; Banerjee, Surajit; Feigley, Andrew et al. (2018) Salt-bridge modulates differential calcium-mediated ligand binding to integrin ?1- and ?2-I domains. Sci Rep 8:2916
Almodovar, Karinna; Iams, Wade T; Meador, Catherine B et al. (2018) Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol 13:112-123
Choby, Jacob E; Grunenwald, Caroline M; Celis, Arianna I et al. (2018) Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis. MBio 9:
Peng, Hui; Zhang, Yixiang; Palmer, Lauren D et al. (2017) Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus. ACS Infect Dis 3:744-755
Polosukhin, Vasiliy V; Richmond, Bradley W; Du, Rui-Hong et al. (2017) Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling. Am J Respir Crit Care Med 195:1010-1021
Celada, Lindsay J; Rotsinger, Joseph E; Young, Anjuli et al. (2017) Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation. Am J Respir Cell Mol Biol 56:74-82
Kinsella, Rachel L; Lopez, Juvenal; Palmer, Lauren D et al. (2017) Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species. J Biol Chem 292:19628-19638
Ichihara, Eiki; Westover, David; Meador, Catherine B et al. (2017) SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer. Cancer Res 77:2990-3000
Hawkins, Charlene; Shaginurova, Guzel; Shelton, D Auriel et al. (2017) Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. J Immunol Res 2017:3642832
Richmond, Bradley W; Brucker, Robert M; Han, Wei et al. (2016) Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun 7:11240

Showing the most recent 10 out of 66 publications