This is the first renewal application for the Vascular Surgery Research Training (VascTrain) Program. The VascTrain program was initially established in 2010 to enhance clinically relevant basic and translational research in vascular surgery trainees and nonclinician trainees with a specific interest in vascular disease and treatment. The program supports 3 training positions each year (6 total positions) with two positions designated for vascular surgery residents and the third position for a trainee from other surgical specialties or a nonMD post-doctoral fellow. The same number and distribution of positions is being requested in this renewal application. The training faculty is composed of 26 trainers from a number of Departments including Surgery, Plastic Surgery, Bioengineering, Medicine, Pathology, Cell Biology, Molecular Genetics and Biochemistry, Pharmacology, Orthopedics and Environmental and Occupational Health. The focus of the training is on cardiovascular disease and is designed to cover three major tracks: Vascular Biology and Disease Pathogenesis/Therapeutics, Bioengineering and Regenerative Medicine, and Clinical Research related to comparative effectiveness, outcomes and vascular disease epidemiology. While these tracks appear to be distinct, training can be customized to incorporate related elements of these areas. In the clinical research track, the trainees will obtain a Masters of Clinical Research degree. Careful selection of a team of mentors that will best support the development of each trainee will be key to the success of the trainees. In the initial funding cycle, the VascTrain Program was very successful in recruiting excellent trainees to the program who have demonstrated good productivity. The program has evolved with recruitment of new training faculty that will further enhance the training experience. The training plan will undergo changes to better develop translational skills, incorporate individually designed curriculum in Responsible Conduct in Research, and focus on unique career development skills for the MD and PhD trainees.

Public Health Relevance

Vascular disease is one of the greatest contributor to morbidity and mortality in Westernized cultures and the incidence is increasing. The study of these processes requires the clinical insight of those professionals who care for these patients who possess a greater understanding of the impact of these conditions on patients and can apply basic scientific findings to the care of such patients. The over goal of this training grant is to support the development of such clinician scientists as well as scientists with greater clinical insight into capable investigators to further the innovation in vascular surgery.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Wang, Wayne C
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University of Pittsburgh
Schools of Medicine
United States
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Mohapatra, Abhisekh; Salem, Karim M; Jaman, Emade et al. (2018) Risk factors for perioperative mortality after revascularization for acute aortic occlusion. J Vasc Surg 68:1789-1795
Mohapatra, Abhisekh; Henry, Jon C; Avgerinos, Efthimios D et al. (2018) Heel Wounds Predict Mortality but Not Amputation after Infrapopliteal Revascularization. Ann Vasc Surg 51:78-85
Haskett, Darren G; Saleh, Kamiel S; Lorentz, Katherine L et al. (2018) An exploratory study on the preparation and evaluation of a ""same-day"" adipose stem cell-based tissue-engineered vascular graft. J Thorac Cardiovasc Surg 156:1814-1822.e3
Xu, Jun; Cui, Xiangdong; Li, Jiehua et al. (2018) Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation. J Vasc Surg 67:910-921
Sridharan, Natalie D; Chaer, Rabih A; Wu, Bryan Boyuan et al. (2018) An Accumulated Deficits Model Predicts Perioperative and Long-term Adverse Events after Carotid Endarterectomy. Ann Vasc Surg 46:97-103
Domenick Sridharan, Natalie; Thirumala, Partha; Chaer, Rabih et al. (2018) Predictors of cross-clamp-induced intraoperative monitoring changes during carotid endarterectomy using both electroencephalography and somatosensory evoked potentials. J Vasc Surg 67:191-198
Sridharan, Natalie D; Boitet, Aureline; Smith, Kenneth et al. (2018) Cost-effectiveness analysis of drug-coated therapies in the superficial femoral artery. J Vasc Surg 67:343-352
Mohapatra, Abhisekh; Lowenkamp, Mikayla N; Henry, Jon C et al. (2018) Prior Endovascular Intervention Is Not Detrimental to Pedal Bypasses for Ischemic Wounds. Ann Vasc Surg 50:80-87
Mohapatra, Abhisekh; Henry, Jon C; Avgerinos, Efthimios D et al. (2018) Bypass versus endovascular intervention for healing ischemic foot wounds secondary to tibial arterial disease. J Vasc Surg 68:168-175
Liang, Nathan L; Reitz, Katherine M; Makaroun, Michel S et al. (2018) Comparable perioperative mortality outcomes in younger patients undergoing elective open and endovascular abdominal aortic aneurysm repair. J Vasc Surg 67:1404-1409.e2

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