This is an application for continuation of the postdoctoral training program in lung biology and disease at the University of Texas Southwestern Medical Center. Training will be directed at the postdoctoral level, and the research training will be for two years in addition to any associated clinical training. The proposal is born out of a collaborative effort between divisions within the Pediatric and Internal Medicine departments involved in lung research at this institute, and is thus interdepartmental at its core. Our training faculty consist of experienced investigators representing 16 different clinical and basic science departments and centers, forming a solid, diverse training force, organized into four thematic tracks: 1) Pulmonary vascular disease;2) Interstitial lung diseases;3) Lung epithelial cell and differentiation disorders;and 4) Immunity/Inflammation/Sepsis. Besides mentor-based teaching, trainees will receive a comprehensive track- and project-specific didactic curriculum. Both clinical and basic science trainees will be guided by an individualized advisory committee that has both basic and clinical science mentors, to broaden the trainee's perspective and facilitate bench to bedside thinking. Emphasis will be placed on maintenance of project focus, creative experimental design, state of the art technology, and careful early career guidance.
Lung diseases continue to account for most of the leading causes of death in the United States. Despite the need for further lung research targeted broadly at basic and clinical levels, there is a national shortage of clinically-directed scientists. The goal of the UT Southwestern Lung Biology and Disease Training program is to provide in-depth research training for postdoctoral fellows involved in adult and pediatric lung disease research, to invest in the future of lung-related research.
|Tanigaki, Keiji; Sacharidou, Anastasia; Peng, Jun et al. (2018) Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance. J Clin Invest 128:309-322|
|Sacharidou, Anastasia; Shaul, Philip W; Mineo, Chieko (2018) New Insights in the Pathophysiology of Antiphospholipid Syndrome. Semin Thromb Hemost 44:475-482|
|Ochoa, Cristhiaan D; Wu, Ru Feng; Terada, Lance S (2018) ROS signaling and ER stress in cardiovascular disease. Mol Aspects Med 63:18-29|
|Sacharidou, Anastasia; Chambliss, Ken L; Ulrich, Victoria et al. (2018) Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. Blood 131:2097-2110|
|Adams, Traci; Newton, Chad; Patel, Hetal et al. (2018) Resident versus faculty member simulation debriefing. Clin Teach 15:462-466|
|Kasiri, Sahba; Shao, Chunli; Chen, Baozhi et al. (2017) GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Res 77:4448-4459|
|Maryoung, Lindley; Yue, Yangbo; Young, Ashley et al. (2017) Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations. J Clin Invest 127:982-986|
|Newton, Chad A; Kozlitina, Julia; Lines, Jefferson R et al. (2017) Telomere length in patients with pulmonary fibrosis associated with chronic lung allograft dysfunction and post-lung transplantation survival. J Heart Lung Transplant 36:845-853|
|Rowe, Regina K; Pyle, David M; Tomlinson, Andrew R et al. (2017) IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol 140:294-298.e8|
|Wu, Ru Feng; Liao, Chengxu; Hatoum, Hadi et al. (2017) RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras. Arterioscler Thromb Vasc Biol 37:98-107|
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