This is a renewal application to fund lung-related research training at the University of Texas Southwestern Medical Center, at the postdoctoral (MD, PhD) level. The proposal is born out of a collaborative effort between the Pediatric and Adult divisions involved in lung research at this Institute, and is thus interdepartmental at its core. Thirty-three experienced investigators and research mentors representing 13 different clinical and basic science departments and centers form a solid, diverse training force. This funding cycle we have reorganized our mentor groupings from a unidimensional track system into a tridimensional matrix that varies along disease focus, translational level, and scientific competency. Trainees may access their primary and secondary mentors through entry into an appropriate point in the matrix and be encouraged to develop along different axes. This structure encourages cross-disciplinary and trans-departmental training, and creates a framework for professional and scientific development. Trainees will receive a comprehensive field- and project-specific didactic curriculum. Both clinical and basic science trainees will be guided by an individualized advisory committee that has both basic and clinical science mentors, to broaden the trainee?s perspective and facilitate bench to bedside thinking. Emphasis will be placed on maintenance of project focus, creative experimental design, state of the art technology, and early career guidance. The strength of this program lies in the highly collaborative Institutional environment, the unique interdepartmental leadership and training faculty of the program, and the experienced and dedicated faculty serving as trainers.
Lung diseases account for most of the leading causes of death in the United States and the rest of the world. Despite the need for further lung research targeted broadly at basic and clinical levels, there is a national shortage of clinically-directed scientists. This grant aims to fund a program to train postdoctoral scientists in both adult and pediatric research programs, to invest in the future of lung-related research.
| Tanigaki, Keiji; Sacharidou, Anastasia; Peng, Jun et al. (2018) Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance. J Clin Invest 128:309-322 |
| Sacharidou, Anastasia; Shaul, Philip W; Mineo, Chieko (2018) New Insights in the Pathophysiology of Antiphospholipid Syndrome. Semin Thromb Hemost 44:475-482 |
| Ochoa, Cristhiaan D; Wu, Ru Feng; Terada, Lance S (2018) ROS signaling and ER stress in cardiovascular disease. Mol Aspects Med 63:18-29 |
| Sacharidou, Anastasia; Chambliss, Ken L; Ulrich, Victoria et al. (2018) Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. Blood 131:2097-2110 |
| Adams, Traci; Newton, Chad; Patel, Hetal et al. (2018) Resident versus faculty member simulation debriefing. Clin Teach 15:462-466 |
| Maryoung, Lindley; Yue, Yangbo; Young, Ashley et al. (2017) Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations. J Clin Invest 127:982-986 |
| Newton, Chad A; Kozlitina, Julia; Lines, Jefferson R et al. (2017) Telomere length in patients with pulmonary fibrosis associated with chronic lung allograft dysfunction and post-lung transplantation survival. J Heart Lung Transplant 36:845-853 |
| Rowe, Regina K; Pyle, David M; Tomlinson, Andrew R et al. (2017) IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol 140:294-298.e8 |
| Wu, Ru Feng; Liao, Chengxu; Hatoum, Hadi et al. (2017) RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras. Arterioscler Thromb Vasc Biol 37:98-107 |
| Kasiri, Sahba; Shao, Chunli; Chen, Baozhi et al. (2017) GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Res 77:4448-4459 |
Showing the most recent 10 out of 32 publications
