This is the second competing renewal application for a Ruth L. Kirschstein Institutional National Research Service Award (T32), which was originally established in 2009 to provide closely mentored, multidisciplinary postdoctoral research training to highly promising physician-scientists and PhDs and prepare them for careers as independent cardiovascular investigators. Since its inception, we have enrolled a total of eighteen trainees, including two under-represented minorities. Almost all graduates of our program have contributed significantly to the cardiovascular literature and a substantial proportion have obtained full-time academic or industry positions engaged in biomedical investigation. Four graduates of the program have been recruited to the faculty of our Division of Cardiology as full-time physician-investigators and all have competed successfully for independent NIH or AHA funding. There are two major changes in this competing renewal application. First, reflecting the growing cadre of faculty at NYU School of Medicine investigating cardiovascular complications of diabetes and metabolic disorders and the tight integration of research in our Divisions of Cardiology and Endocrinology, in this renewal we have renamed this T32 the Training Program in Cardiometabolic Diseases and have named Dr. Ira Goldberg, Director of Endocrinology to the role of co-Program Director (PD). Second, as an anticipated consequence of implementing the ABIM Research Pathway and Clinical Investigator Pathway into our Internal Medicine residency program, we have a growing pipeline of highly talented MD and MD/PhD fellows seeking intensive postdoctoral research training program as the next step in their goal of launching independent research careers. Therefore, we are requesting an expansion of this T32 training program to six positions each year. As in the past, the training program is built upon a foundation of highly accomplished and experienced NIH-funded primary faculty members. The curriculum includes rigorous didactics, a personalized mentoring plan, and an intensive research experience. The training program begins with a broad-based educational curriculum that provides all trainees with a fundamental knowledge-base that stresses research tools and the interface between biomedical research and important manifestations of cardiovascular disease. Trainees will then pursue more specialized coursework and embark upon a substantial laboratory-based or clinical research project under the guidance of a Primary Mentor in one of several areas of institutional strength: Myocardial/Ion Channel Biology and Disease; Vascular Biology and Disease; Metabolic Causes of Cardiovascular Disease, and Clinical Research. Given our track-record, we are confident that continued support for this program will produce a steady pipeline of highly talented and motivated investigators who are committed to enhancing cardiovascular/cardiometabolic health in the United States and elsewhere.

Public Health Relevance

Cardiovascular disease remains the major cause of death in the US. Through the renewal and expansion of this highly successful postdoctoral training program, we align ourselves with the stated goal of the NHLBI to ?provide a sustained flow of qualified physician-scientists able to think critically and translate findings freely between the basic and clinical spheres.? We will accomplish this goal through strong mentorship by established experts in the field, specialized didactics, and intensive training through basic, translational and/or clinical research projects tackling the major forms of cardiovascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
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New York University
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Katz, Stuart; Smilowitz, Nathaniel R; Hochman, Judith S (2018) Another Nail in the Coffin for Intra-Aortic Balloon Counterpulsion in Acute Myocardial Infarction With Cardiogenic Shock. Circulation :
Smilowitz, Nathaniel R; Beckman, Joshua A; Sherman, Scott E et al. (2018) Hospital Readmission After Perioperative Acute Myocardial Infarction Associated With Noncardiac Surgery. Circulation 137:2332-2339
Smilowitz, Nathaniel R; Katz, Gregory; Buyon, Jill P et al. (2018) Systemic lupus erythematosus and the risk of perioperative major adverse cardiovascular events. J Thromb Thrombolysis 45:13-17
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Scacalossi, Kaitlyn R; van Solingen, Coen; Moore, Kathryn J (2018) Long non-coding RNAs regulating macrophage functions in homeostasis and disease. Vascul Pharmacol :
Smilowitz, Nathaniel R (2018) Letter by Smilowitz Regarding Article, ""Three-Vessel Assessment of Coronary Microvascular Dysfunction in Patients With Clinical Suspicion of Ischemia: Prospective Observational Study With the Index of Microcirculatory Resistance"". Circ Cardiovasc Interv 11:e006262
Newman, Jonathan D; Wilcox, Tanya; Smilowitz, Nathaniel R et al. (2018) Influence of Diabetes on Trends in Perioperative Cardiovascular Events. Diabetes Care 41:1268-1274
Heffron, Sean P; Lin, Bing-Xue; Parikh, Manish et al. (2018) Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent. Arterioscler Thromb Vasc Biol 38:245-254
Smilowitz, Nathaniel R; Hausvater, Anais; Reynolds, Harmony R (2018) Hospital Readmission Following Takotsubo Syndrome. Eur Heart J Qual Care Clin Outcomes :
van Solingen, Coen; Scacalossi, Kaitlyn R; Moore, Kathryn J (2018) Long noncoding RNAs in lipid metabolism. Curr Opin Lipidol 29:224-232

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