This is an application for the competing renewal of a T32 postdoctoral training program under the direction of Dr. Allan L. Reiss, Robbins Professor and Vice Chair of Psychiatry and Behavioral Sciences, and Director of the Center for Interdisciplinary Brain Sciences Research (CIBSR) at Stanford University. This training program is situated within an exceptionally diverse and research-intensive environment that is designed to develop new- generation investigators who have the knowledge and skills necessary to conduct innovative, interdisciplinary research at the forefront of child psychiatry and neurodevelopment. Our progress in the current grant period has been exceptional and we have met or exceeded nearly every goal established for the current cycle. The program has attracted a very large pool of first-rate applicants (n=101), filled all funded slots (four per year, total o 11 fellows through June 2016), retained a large majority of trainees for 2 to 3 years of training, and prepared trainees for successful careers as independent investigators. Further, per recommendations from our last review, we have diversified the assignment of mentors for trainees and made co-mentorship a norm. We have also augmented program administrative oversight with the establishment of a Steering Committee and Internal and External Advisory boards. The scientific scope of the program has been expanded with the recruitment of two basic science-oriented fellows and the addition of new senior mentors who are at the forefront of their fields. New junior mentors have been added as well, including two faculty who are graduates of this T32 program. Finally, we have been very successful in attracting trainees who come from an underrepresented minority background or who have a disability (five of 11 fellows). Since its establishment in 1993, our T32 program has trained a total of 44 research fellows who have contributed significantly to the emergence of a diverse and highly trained workforce and have assumed academic leadership roles supportive of the NIMH mission. During the last 10 years of the program specifically, our T32 program graduates have surpassed many accepted indicators of scientific impact including the proportion who are conducting research within academic, industry or non-profit settings (82%), who have received a grant as PI (47%) or who are mentoring others (88%); these T32 graduates have an average overall publication rate of 1.7 papers/year. During the next 5-year grant period, we plan to recruit and retain an additional 9-11 (MD, PhD or MD/PhD) trainees. Specific plans to increase MD or MD/PhD recruitment from the current 3 of 11 fellows to 4-5 of 11 have been established. To meet our goal of significantly expanding the knowledge base and methods toolbox of each trainee, we will continue to establish for each fellow individually tailored didactic, mentorship ad research plans. Using this approach, we focus the trainee's curriculum and research training on bridging traditional, between-discipline gaps in methodology, and on applying interdisciplinary solutions to complex problems in child psychiatry and neurodevelopment.

Public Health Relevance

As many as 1 in 5 children and adolescents in the United States suffer from a debilitating mental or neurodevelopmental disorder; these disorders not only affect children and their families, but have far-reaching effects on multiple aspects of our society. A clear impetus must be placed on training new researchers who are at the forefront of scientific investigation that leads to prevention or more effective treatment of children with thes disorders. This training grant directly addresses this issue by preparing new-generation investigators to have the knowledge and skills necessary to conduct innovative, interdisciplinary research at the forefront of child psychiatry and neurodevelopment.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZMH1)
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Bechtholt, Anita J
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Stanford University
Schools of Medicine
United States
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Karhson, Debra S; Krasinska, Karolina M; Dallaire, Jamie Ahloy et al. (2018) Plasma anandamide concentrations are lower in children with autism spectrum disorder. Mol Autism 9:18
Mueller, Adrienne; Hong, David S; Shepard, Steven et al. (2017) Linking ADHD to the Neural Circuitry of Attention. Trends Cogn Sci 21:474-488
Fung, Lawrence K; Reiss, Allan L (2016) Moving Toward Integrative, Multidimensional Research in Modern Psychiatry: Lessons Learned From Fragile X Syndrome. Biol Psychiatry 80:100-111
Baker, Joseph M; Reiss, Allan L (2016) A meta-analysis of math performance in Turner syndrome. Dev Med Child Neurol 58:123-30
Saggar, Manish; Vrticka, Pascal; Reiss, Allan L (2016) Understanding the influence of personality on dynamic social gesture processing: An fMRI study. Neuropsychologia 80:71-78
Quintin, Eve-Marie; Jo, Booil; Hall, Scott S et al. (2016) The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence. Dev Psychopathol 28:1457-1469
Klabunde, Megan; Saggar, Manish; Hustyi, Kristin M et al. (2015) Neural correlates of self-injurious behavior in Prader-Willi syndrome. Hum Brain Mapp 36:4135-43
Garrett, A; Gupta, S; Reiss, A L et al. (2015) Impact of 5-HTTLPR on hippocampal subregional activation in older adults. Transl Psychiatry 5:e639
Saggar, Manish; Hosseini, S M Hadi; Bruno, Jennifer L et al. (2015) Estimating individual contribution from group-based structural correlation networks. Neuroimage 120:274-84
Roybal, Donna J; Barnea-Goraly, Naama; Kelley, Ryan et al. (2015) Widespread white matter tract aberrations in youth with familial risk for bipolar disorder. Psychiatry Res 232:184-92

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