The central objective of this predoctoral training program in Neuroscience is to provide individualized, high quality training to predoctoral students in their first two years of graduate studies, before they start their dissertation research. We provide broad, multi-disciplinary training at all levels with a strong foundation in core concepts, skills, methodologies, and advanced comprehension of the scientific literature. Our newly revised core curriculum instructs students at the level of genes, cells, systems, cognition, translational neuroscience, and diseases of the nervous system. We foster an environment unconstrained by traditional discipline boundaries and where graduate students are encouraged to work at the interfaces of these disciplines. At all stages of instruction we integrate skills considered essential for successful, independent research careers in neuroscience. These include critical thinking and reasoning, effective science writing and oral presentation, knowledge of scientific review processes, and training in ethics. This year we also have introduced new initiatives to ensure our graduate students are exposed to clinical and disease concepts in neuroscience. These include incorporating seminars from clinicians at Brown into our core curriculum and attendance at select Grand Rounds in Neurology and Neuropathology at Rhode Island Hospital. The majority of our predoctoral trainees continue in basic scientific investigations of the nervous system either in academia or in the biotechnology industry. We expect that exposure to clinical issues early in their training will positively influence their research careers. Key features of the Neuroscience Graduate Program at Brown include: Excellence in research along with excellence in education and mentorship; a history of interdisciplinary and translational research particularly in computational neuroscience; and an environment of small but highly productive laboratories where graduate students are equal partners in the research process. The proposed training program has 26 participating faculty, drawn from six different Brown University departments and 30-35 predoctoral trainees. The faculty trainers are a distinguished and energetic group of brain scientists that collectively cover the spectrum of modern neuroscience research from genes to cognition. We have structures in place that encourage and facilitate research in computational and translational neuroscience that reside at the interface of disciplines including engineering, applied mathematics and neuroscience. Our training also covers the full-spectrum of state-of-the art methodologies that we consider essential for a successful career in the neurosciences. These include non-invasive functional MRI, applications of robotics and neuroprosthetics, advanced electrophysiological recordings, mouse transgenics, behavioral studies, molecular manipulations of neuronal genes, and functional proteomics. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH020068-08
Application #
7492206
Study Section
Special Emphasis Panel (ZMH1-ERB-Y (01))
Program Officer
Desmond, Nancy L
Project Start
1999-07-01
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
8
Fiscal Year
2008
Total Cost
$218,114
Indirect Cost
Name
Brown University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Wang, Ailin; Conicella, Alexander E; Schmidt, Hermann Broder et al. (2018) A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J 37:
Atkinson, Elizabeth Grace; Audesse, Amanda Jane; Palacios, Julia Adela et al. (2018) No Evidence for Recent Selection at FOXP2 among Diverse Human Populations. Cell 174:1424-1435.e15
Ryan, Veronica H; Dignon, Gregory L; Zerze, Gül H et al. (2018) Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. Mol Cell 69:465-479.e7
Lauro, Peter M; Lee, Shane; Ahn, Minkyu et al. (2018) DBStar: An Open-Source Tool Kit for Imaging Analysis with Patient-Customized Deep Brain Stimulation Platforms. Stereotact Funct Neurosurg 96:13-21
Boeynaems, Steven; Bogaert, Elke; Kovacs, Denes et al. (2017) Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Mol Cell 65:1044-1055.e5
Yalcin, Emine B; McLean, Tory; Tong, Ming et al. (2017) Progressive white matter atrophy with altered lipid profiles is partially reversed by short-term abstinence in an experimental model of alcohol-related neurodegeneration. Alcohol 65:51-62
O'Hern, Patrick J; do Carmo G Gonçalves, Inês; Brecht, Johanna et al. (2017) Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. Elife 6:
Asaad, Wael F; Lauro, Peter M; Perge, János A et al. (2017) Prefrontal Neurons Encode a Solution to the Credit-Assignment Problem. J Neurosci 37:6995-7007
Monahan, Zachary; Ryan, Veronica H; Janke, Abigail M et al. (2017) Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. EMBO J 36:2951-2967
Bath, K; Manzano-Nieves, G; Goodwill, H (2016) Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice. Horm Behav 82:64-71

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