The Department of Psychiatry at Yale University School of Medicine requests the first renewal of a 5 year post-doctoral research training grant for intervention and services research in treatment, rehabilitation, and prevention of severe mental disorders. This grant provides support for a total of 2 physicians and 2 Ph.D. psychologists per year. Post-doctoral trainees spend two to three years at Yale to obtain clinical and research training while being mentored by faculty investigators whose interests include neuroscience, cognitive and vocational rehabilitation, early intervention, epidemiology and health services research. Our multi-disciplinary program enables trainees to engage in research from trials on promising new approaches to effectiveness studies in health systems. The main purpose of this proposal is to provide post-doctoral trainees the opportunity to devote full-time effort to learning the skills needed to become independent researchers and clinician scientists. Prospective trainees identify a faculty mentor and develop a proposed training plan as part of the application procedure. During the training program, trainees participate in seminars and courses on health services research, neuroscience, biostatistics, research design, translational research and responsible conduct of scientific research. They participate in a mentored rotation on the IRB. Direct involvement in community settings, stimulation of cutting-edge neuroscience, exposure to systems issues at a state, national, and international level, and intensive training in research methods provide a rich experience that encourages trainees to generate original research. Projects have included such topics as early detection of psychosis, the recovery process, changing patterns of child psychiatric services, mental health services for the deaf and hearing impaired, cognitive remediation in substance abuse treatment, and fMRI assessment of cognitive retraining in schizophrenia. Under faculty mentors, trainees gain experience in clinical research, from initial conceptualization and design, through implementation, data analysis and manuscript preparation. Four fellows have completed their training and four are currently in training. Graduates have continued their independent research as faculty at leading medical centers.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
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Study Section
Special Emphasis Panel (ZMH1-ERB-I (01))
Program Officer
Hill, Lauren D
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Yale University
Schools of Medicine
New Haven
United States
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Wilkinson, Samuel T; Kiselycznyk, Carly; Banasr, Mounira et al. (2018) Serum and plasma brain-derived neurotrophic factor and response in a randomized controlled trial of riluzole for treatment resistant depression. J Affect Disord 241:514-518
Wilkinson, Samuel T; Ballard, Elizabeth D; Bloch, Michael H et al. (2018) The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. Am J Psychiatry 175:150-158
Wilkinson, Samuel T; Agbese, Edeanya; Leslie, Douglas L et al. (2018) Identifying Recipients of Electroconvulsive Therapy: Data From Privately Insured Americans. Psychiatr Serv 69:542-548
Davidson, Charlie A; Lesser, Rebecca; Parente, Lori T et al. (2018) Psychometrics of social cognitive measures for psychosis treatment research. Schizophr Res 193:51-57
Wilkinson, Samuel T; Katz, Rachel B; Toprak, Mesut et al. (2018) Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital. J Clin Psychiatry 79:
van Schalkwyk, Gerrit I; Wilkinson, Samuel T; Davidson, Larry et al. (2018) Acute psychoactive effects of intravenous ketamine during treatment of mood disorders: Analysis of the Clinician Administered Dissociative State Scale. J Affect Disord 227:11-16
Wilkinson, Samuel T; Rosenheck, Robert A (2017) Electroconvulsive Therapy at a Veterans Health Administration Medical Center. J ECT 33:249-252
Adams, Thomas G; Bloch, Michael H; Pittenger, Christopher (2017) Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder. J Clin Psychopharmacol 37:269-271
Wilkinson, Samuel T; Sanacora, Gerard; Bloch, Michael H (2017) Hippocampal volume changes following electroconvulsive therapy: a systematic review and meta-analysis. Biol Psychiatry Cogn Neurosci Neuroimaging 2:327-335
Wilkinson, Samuel T; Wright, DaShaun; Fasula, Madonna K et al. (2017) Cognitive Behavior Therapy May Sustain Antidepressant Effects of Intravenous Ketamine in Treatment-Resistant Depression. Psychother Psychosom 86:162-167

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