This is the second renewal of Mount Sinai's Jointly Sponsored Institutional Predoctoral T32 Training Program in Neuroscience. The objective of the Training Program is to provide rigorous, broad-based, individualized and multidisciplinary training to Year 1 and 2 predoctoral students in basic, translational and clinical neuroscience research, thereby enhancing the ability of our trainees to acquire critical skillsets necessary for high-quality doctoral dissertation research and a productive and impactful career in the science- related workforce. To accomplish this, the Training Program leverages the intimate association between the Mount Sinai Hospital and Health System, the Icahn School of Medicine at Mount Sinai and Mount Sinai's Graduate School of Biomedical Sciences, physically embedded together under one leadership, to expose trainees to the enormous breadth of basic, translational and clinical scientific approaches and model systems represented by an outstanding training faculty, ranging from structure/function analysis of individual synapses, to computational modeling of gene, protein and connectivity networks in healthy and diseased brains, to behavioral, electrophysiological and imaging studies of a variety of organisms, including humans. Mount Sinai has undergone an enormous expansion in basic and clinical research infrastructure, neuroscience faculty recruitment and a 3-fold increase in applications to the Neuroscience PhD program. Thus, seven training slots per year are requested. Our trainees participate in an integrated program of Core courses (spanning genes, molecules, cells, synapses, circuits, systems, behaviors and brain pathophysiology) and includes a course with direct patient contact. Courses are team-taught by an exceptional faculty using different teaching styles, including flipped classrooms and other approaches. Additional first-year courses include Responsible Conduct in Research, Rigor and Reproducibiity, an intensive Biostatistics course (with a parallel lab in R-programming) a Journal Club/WIP and research rotations. By the end of the first year, trainees select a thesis lab, and during their second year, commence dissertation research while taking at least two Advanced Electives from a large number of courses offered across the Institution. This allows each trainee to customize their coursework to their particular research and training goal needs. Trainees in our program also benefit from numerous activities that enhance their research experience, including science theme-based Clubs, seminars, career development opportunities, teaching and peer-mentoring activities, an annual retreat and other cohesion-building events. This Neuroscience Training Program T32 is essential to Mount Sinai's mission of providing fundamental neuroscience research training to our students, and serves as the principal research training, mentoring and financial engine driving specifically early-stage predoctoral students seeking a PhD in Neuroscience.

Public Health Relevance

The Neuroscience Training Program at Mount Sinai provides rigorous, broad-based, individualized and multidisciplinary training to Year 1 and 2 predoctoral students in basic and translational neuroscience research, including research with a disease-focus. The goal of the Program is to enhance the ability of our trainees to acquire critical skillsets necessary for high-quality doctoral dissertation research and a productive and impactful career in the science-related workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
2T32MH087004-11
Application #
9909052
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Van'T Veer, Ashlee V
Project Start
2009-07-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
11
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Pfau, Madeline L; Ménard, Caroline; Russo, Scott J (2018) Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities. Annu Rev Pharmacol Toxicol 58:411-428
Aleyasin, Hossein; Flanigan, Meghan E; Golden, Sam A et al. (2018) Cell-Type-Specific Role of ?FosB in Nucleus Accumbens In Modulating Intermale Aggression. J Neurosci 38:5913-5924
Zhang, Song; Zhang, Hongxing; Ku, Stacy M et al. (2018) Sex Differences in the Neuroadaptations of Reward-related Circuits in Response to Subchronic Variable Stress. Neuroscience 376:108-116
Steinmetz, Adam B; Stern, Sarah A; Kohtz, Amy S et al. (2018) Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice. J Neurosci 38:1015-1029
Mitchell, A C; Javidfar, B; Pothula, V et al. (2018) MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Mol Psychiatry 23:123-132
Heshmati, Mitra; Aleyasin, Hossein; Menard, Caroline et al. (2018) Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility. Proc Natl Acad Sci U S A 115:1111-1116
Liu, Di; Tang, Qian-Qian; Yin, Cui et al. (2018) Brain-derived neurotrophic factor-mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry. Pain 159:175
Devarakonda, Kavya; Stanley, Sarah (2018) Investigating metabolic regulation using targeted neuromodulation. Ann N Y Acad Sci 1411:83-95
Jiang, C; Lin, W-J; Sadahiro, M et al. (2018) VGF function in depression and antidepressant efficacy. Mol Psychiatry 23:1632-1642
Labonté, Benoit; Engmann, Olivia; Purushothaman, Immanuel et al. (2017) Sex-specific transcriptional signatures in human depression. Nat Med 23:1102-1111

Showing the most recent 10 out of 74 publications