The purpose of the program is to provide future research workers and future faculty members with both predoctoral and postdoctoral training in neuropharmacology. The program will capitalize on the scientific strength and diversity of talent in the training faculty. The research includes a wide range of methodological approaches not normally found in a department of Pharmacology such as genetics, molecular biology, cell biology, structural biophysics, electrophysiology, as well as more conventional biochemical and systemic techniques. Predoctoral trainees will be selected by an admission committee from the applicant pool of recently graduated college students, usually with majors in the biological or physical sciences. Postdoctoral trainees will be drawn from recently graduated M.D.s and PhD.s who are applying to the faculty members, who are interested in neuropharmacological research, and who excel in their qualifications. Training in neuropharmacology is offered with emphasis on drug interaction with the central and peripheral nervous system. It covers both basic molecular science as well as applied, disease-oriented neuropharmacology, including topics such as the mechanism of synthesis and release -of neurotransmitters, the molecular basis of receptor-mediated signal transduction and of signal conduction, the function of dopaminergic and other aminergic pathways, and approaches to further our understanding of diseases such as parkinsonism and drug addiction. The quality of the training is ascertained by the teaching faculty, many of whom are national and international leaders in their fields. Predoctoral training is rigorous and comprehensive, including three rotations through three different laboratories. Postdoctoral trainees can choose from a wide and diverse range of research seminars including a departmental seminar series. In addition, their research training will benefit from the many scientific interactions between the participating laboratories.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007136-18
Application #
2668889
Study Section
NST-2 Subcommittee (NST)
Program Officer
Streicher, Eugene
Project Start
1979-08-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Cho, Yoonsang; Vermeire, Jon J; Merkel, Jane S et al. (2011) Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chem Biol 18:1089-101
Cho, Yoonsang; Crichlow, Gregg V; Vermeire, Jon J et al. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A 107:11313-8
Chiswell, Brian P; Stiegler, Amy L; Razinia, Ziba et al. (2010) Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J Struct Biol 170:157-63
Hoopes, James T; Liu, Xuying; Xu, Xiaomeng et al. (2010) Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem 285:2165-73
Chiswell, Brian P; Zhang, Rong; Murphy, James W et al. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A 105:20677-82
Zito, Christina I; Qin, Hui; Blenis, John et al. (2007) SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem 282:6946-53
Murphy, James W; Cho, Yoonsang; Sachpatzidis, Aristidis et al. (2007) Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem 282:10018-27
Kontaridis, Maria I; Eminaga, Seda; Fornaro, Mara et al. (2004) SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol 24:5340-52
Ivins Zito, Christina; Kontaridis, Maria I; Fornaro, Mara et al. (2004) SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol 199:227-36
Kontaridis, Maria I; Liu, Xiangdong; Zhang, Lei et al. (2002) Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol 22:3875-91

Showing the most recent 10 out of 20 publications