The purpose of the program is to give both predoctoral and postdoctoral training in neuropharmacology to future research workers and future faculty members. The program will capitalize on the wide diversity of talent in the training faculty, who include individuals whose approaches would normally be found not just in a department of Pharmacology, but also approaches more commonly found in departments of Anatomy, Biochemistry, Biophysics, Physiology and Psychiatry. The approach thus will be multidisciplinary: Predoctoral trainees will be recruited from recently graduated college students, usually with majors in the biological or physical sciences; and postdoctoral trainees will be drawn from recently graduated Ph.D's in a variety of fields (Biochemistry, Physiology, Biophysics and Molecular Biology, for example) and M.D's. Training in neuropharmacology is offered with general emphasis on drugs as they elucidate, and modify: the mechanism of synthesis, storage and release of neurotransmitters and neuromodulators; the molecular basis of conduction; the relations between metabolism and function in nervous tissue; and the importance of these parameters in health and disease. The specific areas of research training will all be in the areas of expertise of the senior neuropharmacologists in the department. In addition, advanced seminar courses in neuropharmacology as well as seminar programs in general pharmacology are available.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007136-23
Application #
6768580
Study Section
NST-2 Subcommittee (NST)
Program Officer
Mitler, Merrill
Project Start
1979-08-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
23
Fiscal Year
2004
Total Cost
$285,793
Indirect Cost
Name
Yale University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Cho, Yoonsang; Vermeire, Jon J; Merkel, Jane S et al. (2011) Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chem Biol 18:1089-101
Cho, Yoonsang; Crichlow, Gregg V; Vermeire, Jon J et al. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A 107:11313-8
Chiswell, Brian P; Stiegler, Amy L; Razinia, Ziba et al. (2010) Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J Struct Biol 170:157-63
Hoopes, James T; Liu, Xuying; Xu, Xiaomeng et al. (2010) Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem 285:2165-73
Chiswell, Brian P; Zhang, Rong; Murphy, James W et al. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A 105:20677-82
Zito, Christina I; Qin, Hui; Blenis, John et al. (2007) SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem 282:6946-53
Murphy, James W; Cho, Yoonsang; Sachpatzidis, Aristidis et al. (2007) Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem 282:10018-27
Ivins Zito, Christina; Kontaridis, Maria I; Fornaro, Mara et al. (2004) SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol 199:227-36
Kontaridis, Maria I; Eminaga, Seda; Fornaro, Mara et al. (2004) SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol 24:5340-52
Kontaridis, Maria I; Liu, Xiangdong; Zhang, Lei et al. (2002) Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol 22:3875-91

Showing the most recent 10 out of 20 publications