This revised application requests funds to initiate a new predoctoral and postdoctoral training program in basic neuroscience as it relates to neurodegenerative disease. The program will build on existing training programs, an NINDS-funded Program Project on basal ganglia and parkinsonism headed by the program Director of this application. These training and research programs have already helped to develop and integrate diverse elements of the basic neuroscience community at the University of Pittsburgh and to strengthen its ties to clinical neuroscience. If funded, the addition of pre- and postdoctoral positions provided by NINDS would provide the critical mass needed to recruit the best possible pre- and postdoctoral students (including underrepresented minority students) and to offer a training program of the highest quality. Our proposed program focusses primarily on research training. However, predoctoral students will take a series of core courses in neuroscience and other areas of basic biological science, a course in clinical neuroscience, and advanced seminars, and pass through a series of """"""""milestones,"""""""" including a comprehensive exam. Postdoctoral trainees will attend courses and seminars as needed. In addition, both groups will participate actively in a series of professional development workshops. These workshops provide explicit training in such """"""""survival skills"""""""" as written and oral communication, obtaining jobs and grants, teaching and managing a research lab. Training in responsible conduct is an integral part of both the survival skill workshops and the core curriculum itself. Students are encouraged to consider a wide range of employment opportunities within which to exercise their skills in research and seminars are held to permit them to become familiar with employment both within and outside of traditional academic research universities. Members of the training faculty come primarily from the Department of Neuroscience. Other participating departments and centers include the Departments of Neurobiology, Neurology, Pathology, and Pharmacology, Psychiatry, and the Center for Neuroscience. Two groups of faculty are described: a core group of full faculty , consisting of individuals with extensive experience in training and in research, and a small group of """"""""pro- faculty"""""""" who have outstanding promise and will be available to serve as co-mentors in conjunction with a more senior faculty member. Data are provided to support our belief that we will be able to obtain outstanding trainees for the proposed program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007391-03
Application #
2883566
Study Section
NST-2 Subcommittee (NST)
Program Officer
Heemskerk, Jill E
Project Start
1997-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Neurosciences
Type
Schools of Arts and Sciences
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Poplawsky, Alexander John; Fukuda, Mitsuhiro; Kang, Bok-Man et al. (2017) Dominance of layer-specific microvessel dilation in contrast-enhanced high-resolution fMRI: Comparison between hemodynamic spread and vascular architecture with CLARITY. Neuroimage :
Ruff, Douglas A; Cohen, Marlene R (2017) A normalization model suggests that attention changes the weighting of inputs between visual areas. Proc Natl Acad Sci U S A 114:E4085-E4094
Poplawsky, Alexander John; Fukuda, Mitsuhiro; Kim, Seong-Gi (2017) Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models. Neuroimage :
Oby, Emily R; Perel, Sagi; Sadtler, Patrick T et al. (2016) Extracellular voltage threshold settings can be tuned for optimal encoding of movement and stimulus parameters. J Neural Eng 13:036009
Ruff, Douglas A; Cohen, Marlene R (2016) Stimulus Dependence of Correlated Variability across Cortical Areas. J Neurosci 36:7546-56
Murphy, Matthew C; Poplawsky, Alexander J; Vazquez, Alberto L et al. (2016) Improved spatial accuracy of functional maps in the rat olfactory bulb using supervised machine learning approach. Neuroimage 137:1-8
Ruff, Douglas A; Cohen, Marlene R (2016) Attention Increases Spike Count Correlations between Visual Cortical Areas. J Neurosci 36:7523-34
Poplawsky, Alexander John; Fukuda, Mitsuhiro; Murphy, Matthew et al. (2015) Layer-Specific fMRI Responses to Excitatory and Inhibitory Neuronal Activities in the Olfactory Bulb. J Neurosci 35:15263-75
Iordanova, Bistra; Vazquez, Alberto L; Poplawsky, Alexander J et al. (2015) Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex. J Cereb Blood Flow Metab 35:922-32
Van Laar, Victor S; Roy, Nikita; Liu, Annie et al. (2015) Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol Dis 74:180-93

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