This competitive renewal application requests 5 additional years support for 4 post-doctoral trainees in cerebrovascular disease (stroke). The last 5 years of funding under the T32 Training Grant mechanism has resulted in significant growth in our program on many fronts. Continued funding of this Stroke Program Training Grant will allow us to train ethnically diverse researchers and physician-scientists who will make an impact in treating this disease. Our overall goal is to help accomplish improved care of stroke patients by mentoring clinician-scientists who will dedicate their careers to investigating the pathophysiology and epidemiology of cerebrovascular disease and the application of this knowledge to new therapeutic advances. Our trainees'activities during their mentored two-year program ranges from bench to bedside, from the medical school lecture hall to Emergency Departments and paramedic stations, and from computerized databases to the community. The current faculty and their areas of special focus includes James Grotta MD (director, laboratory and clinical research in acute stroke therapy), Sean Savitz MD (co-director, laboratory, stem cell research), Jaroslaw Aronowski PhD (animal stroke models and inflammatory response to injury), Xiurong Zhao MD (animal stroke models and inflammatory response to injury), Kachikwu Illoh MD (neuro-immulogy), Nicole Gonzales MD (stroke prevention and clinical trial design), Jon Tyson (clinical research training, education). The program also includes a rich network of laboratory and clinical collaborators, and a history of academically productive graduates. The trainees have three primary spheres of activity;the development and execution of individual research projects, participation in clinical research protocols, and care of stroke patients at Hermann Hospital where trainees supervise and teach neurology residents and sharpen their academic skills. Potential trainees must have completed a neurology residency and demonstrate a commitment to a career carrying out research in cerebrovascular disease. Each fellowship will last two years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007412-12
Application #
7869268
Study Section
Special Emphasis Panel (ZNS1-SRB-P (47))
Program Officer
Korn, Stephen J
Project Start
1998-07-06
Project End
2014-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
12
Fiscal Year
2010
Total Cost
$270,089
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Neurology
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Sarraj, Amrou; Hassan, Ameer; Savitz, Sean I et al. (2018) Endovascular Thrombectomy for Mild Strokes: How Low Should We Go? Stroke 49:2398-2405
Berekashvili, Ketevan; Soomro, Jazba; Shen, Loren et al. (2018) Safety and Feasibility of Argatroban, Recombinant Tissue Plasminogen Activator, and Intra-Arterial Therapy in Stroke (ARTSS-IA Study). J Stroke Cerebrovasc Dis 27:3647-3651
Zha, Alicia; Vahidy, Farhaan; Randhawa, Jaskaren et al. (2018) Association Between Splenic Contraction and the Systemic Inflammatory Response After Acute Ischemic Stroke Varies with Age and Race. Transl Stroke Res 9:484-492
Barreto, Andrew D; Ford, Gary A; Shen, Loren et al. (2017) Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke). Stroke 48:1608-1616
Vahidy, Farhaan; Nguyen, Claude; Albright, Karen C et al. (2016) Transferring Patients with Intracerebral Hemorrhage Does Not Increase In-Hospital Mortality. PLoS One 11:e0159174
Karamchandani, Rahul R; Vahidy, Farhaan; Bajgur, Suhas et al. (2015) Early depression screening is feasible in hospitalized stroke patients. PLoS One 10:e0128246
Nguyen, Claude; Mir, Osman; Vahidy, Farhaan et al. (2015) Resource Utilization for Patients with Intracerebral Hemorrhage Transferred to a Comprehensive Stroke Center. J Stroke Cerebrovasc Dis 24:2866-74
Elliott, Andrea; Wetzel, Jeremy; Roper, Tiffany et al. (2015) Thromboelastography in patients with acute ischemic stroke. Int J Stroke 10:194-201
Bowry, Ritvij; Fraser, Stuart; Archeval-Lao, Joancy M et al. (2014) Thrombelastography detects the anticoagulant effect of rivaroxaban in patients with stroke. Stroke 45:880-3
Alderazi, Yazan J; Barot, Niravkumar V; Peng, Hui et al. (2014) Clotting factors to treat thrombolysis-related symptomatic intracranial hemorrhage in acute ischemic stroke. J Stroke Cerebrovasc Dis 23:e207-14

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