This proposal seeks to continue the training program in Translational Research in Neurology that has been based in the Department of Neurology at the Emory University School of Medicine. Emory has a large and outstanding faculty who perform cutting edge neurodegenerative disease research. The objective of this program is to provide two predoctoral and three postdoctoral research training opportunities for individuals interested in pursuing careers in neurotranslational research and to ensure that a diverse and highly trained workforce is available to assume leadership roles related to translational research. Trainees will carry out supervised research with the primary objective of developing their research skills and knowledge in the field of neurological disease with mentors with exceptional scientific and teaching experience from both basic neuroscience and clinical research for a period of one year. Trainees will be prepared to utilize their research findings as they pursue future careers in research, in academia or in industry. Our program will also provide trainees with training in grant writing so they can obtain future independent research support. Postdocs will also receive training in laboratory and project management. We will provide an outstanding interactive and interdisciplinary environment for learning to design and carry out research investigations that are relevant to neurological disease. The training has 2 main components: First, trainees are immersed in an intensive, hands-on laboratory training program. Second, they learn clinical aspects of neurological disorders, including current concepts of pathogenesis and pathophysiology, current therapy and potential targets for experimental therapeutic intervention. We anticipate recruiting students and PhDs with research experience but little practical knowledge of neurologic disease, and MDs with a firm grasp of clinical neurology but little practical research experience. We will also recruit MD-PhDs who have completed clinical training and now wish to re-tool for a career in neurological research. The faculty who will serve as training mentors are experienced clinician-scientists or basic neuroscientists working on translational research in the Departments of Neurology, Cell Biology, Pharmacology, Human Genetics, Neurosurgery and other clinical and basic science departments.
To provide predoctoral and postdoctoral research training opportunities for individuals interested in pursuing careers in neurotranslational research by understanding mechanisms of neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, epilepsy and stroke, in order to develop new treatments and therapeutic targets.
|Umoh, Mfon E; Dammer, Eric B; Dai, Jingting et al. (2018) A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain. EMBO Mol Med 10:48-62|
|Abreha, Measho H; Dammer, Eric B; Ping, Lingyan et al. (2018) Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease. Proteomics 18:e1800108|
|Moody, Olivia A; Jenkins, Andrew (2018) The role of loops B and C in determining the potentiation of GABAA receptors by midazolam. Pharmacol Res Perspect 6:e00433|
|MacPherson, Kathryn P; Sompol, Pradoldej; Kannarkat, George T et al. (2017) Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice. Neurobiol Dis 102:81-95|
|Holler, Christopher J; Taylor, Georgia; Deng, Qiudong et al. (2017) Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. eNeuro 4:|
|Christopher, Michael A; Kyle, Stephanie M; Katz, David J (2017) Neuroepigenetic mechanisms in disease. Epigenetics Chromatin 10:47|
|Giddens, Michelle M; Wong, Jennifer C; Schroeder, Jason P et al. (2017) GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis 106:181-190|
|Sanders, Teresa H (2017) Stimulation of Cortico-Subthalamic Projections Amplifies Resting Motor Circuit Activity and Leads to Increased Locomotion in Dopamine-Depleted Mice. Front Integr Neurosci 11:24|
|Rorabaugh, Jacki M; Chalermpalanupap, Termpanit; Botz-Zapp, Christian A et al. (2017) Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain 140:3023-3038|
|Moody, Olivia A; Talwar, Sahil; Jenkins, Meagan A et al. (2017) Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details. Ann Neurol 81:904-907|
Showing the most recent 10 out of 68 publications