?s Abstract): This new proposal is a request for funding of a broadly-based Post-doctoral Training Program in General Motor Control Mechanisms and Disease from the Northwestern University Institute for Neuroscience (NUIN). This training program has grown out of a multidisciplinary group of motor control investigators who have collaborated since the inception of the NUIN in 1989. The program will be directed by Dr. D. James Surmeier with the assistance of Dr. Enrico Mugnaini (Associate Director) and a Steering Committee. Trainees will conduct their research under the guidance of 29 mentors working in motor control research from 11 departments of 3 schools on the Chicago and Evanston campuses of Northwestern University. The proposal requests support for 6 post-doctoral and 2 pre-doctoral trainees. Postdoctoral trainees will be selected on the basis of previous training and research plan. Pre-doctoral trainees will be selected from NUIN and Medical Scientist Training Program Ph.D. programs on the basis of course performance, laboratory rotations and the relevance of dissertation research to the goals of the training program. A concerted effort will be made to recruit women and minorities to the program. The program will offer a broad range of interdisciplinary research and training opportunities in the neuroscience of somatic and autonomic motor control. The research of participating preceptors spans molecular and cellular neuroscience, systems neuroscience, clinical and behavioral neuroscience and computational neuroscience. The mentor faculty will assist and monitor the trainee?s progress through formal advising and evaluations, and through formal classroom and informal discussions (in journal clubs, laboratory meetings and research clubs). An feature of the training program is that it brings together researchers in fundamental and clinical neuroscience, providing a highly productive, interdisciplinary research environment for trainees in motor control and related motor system diseases at Northwestern University. In addition to providing research training, the program will help trainees to develop skills in written and oral communication, grant writing, networking and career development. A clear awareness of ethical issues facing neuroscientists and a responsible conduct in science will be a primary training goal. The program outlines attempts to exemplify the multidisciplinary and interactive type of neuroscience research training encouraged by NIH.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS041234-02
Application #
6531140
Study Section
NST-2 Subcommittee (NST)
Program Officer
Michel, Mary E
Project Start
2001-07-15
Project End
2006-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$363,063
Indirect Cost
Name
Northwestern University at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wong, Yvette C; Ysselstein, Daniel; Krainc, Dimitri (2018) Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554:382-386
Cherry, Jonathan J; DiDonato, Christine J; Androphy, Elliot J et al. (2017) In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PLoS One 12:e0185079
Chu, Hong-Yuan; McIver, Eileen L; Kovaleski, Ryan F et al. (2017) Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5
Burbulla, Lena F; Song, Pingping; Mazzulli, Joseph R et al. (2017) Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science 357:1255-1261
Valdez, Clarissa; Wong, Yvette C; Schwake, Michael et al. (2017) Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Hum Mol Genet 26:4861-4872
Glajch, Kelly E; Kelver, Daniel A; Hegeman, Daniel J et al. (2016) Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci 36:5472-88
Wong, Yvette C; Krainc, Dimitri (2016) Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease. Mov Disord 31:1610-1618
Cooper, Garry; Lasser-Katz, Efrat; Simchovitz, Alon et al. (2015) Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 114:1513-20
Suter, Benjamin A; Shepherd, Gordon M G (2015) Reciprocal interareal connections to corticospinal neurons in mouse M1 and S2. J Neurosci 35:2959-74
Rafalovich, Igor V; Melendez, Alexandria E; Plotkin, Joshua L et al. (2015) Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Cell Rep 13:1336-1342

Showing the most recent 10 out of 51 publications