This is the second competitive renewal application for the Training Program in Neurobiology of Cognition and Cognitive Disorders at the University of Alabama at Birmingham (C&CD Program). The C&CD Program is housed in the Department of Neurobiology, and includes 43 faculty from 15 basic science and clinical departments in the School of Medicine (SOM), School of Optometry, and College of Arts and Sciences. The success of the C&CD Program in its recent funding period is evidenced by its robust participation (34 total students), graduation of a talented cadre of doctoral students (25 PhDs graduated-5 URMs), with an average of more than four publications each, and all transitioning to competitive postdoctoral positions or completing clinical training. The overall goal of the C&CD Program is to create the next generation of talented, diverse and independent scholars and leaders in cognitive neurobiology. These responsible individuals will have (1) a solid foundation in molecular, cellular and cognitive neuroscience theories and findings, (2) training in the mechanisms for translating basic research into advancements in the treatment of cognitive disorders, and (3) be well-prepared to employ a multidisciplinary research approach using skill sets encompassing the next generation of tools and technologies to address important questions in cognitive neurobiology. The specific ?value added? components of the C&CD Program include the special clinical/translational training experience in patient- oriented research, interactions with both basic science and clinician scientist mentors, and distinct extracurricular activities. The UAB SOM has planned expansions for the Department of Neurobiology and Clinical Neuroscience with investments in areas relevant to cognition and cognitive disorders, thus providing a supportive environment for the future of the C&CD Program which will benefit substantially from this investment with the addition of dynamic new faculty mentors and research facilities.

Public Health Relevance

Project Narative The UAB T32 Predoctoral Training Program in Neurobiology of Cognition and Cognitive Disorders program (C&CD Program) is dedicated to training the next generation of talented, diverse and independent scholars and leaders in cognitive neurobiology. These responsible individuals from the UAB Graduate Biomedical Sciences (GBS) and UAB Medical Scientist Training (MSTP) Programs will have a solid foundation in molecular, cellular and cognitive neuroscience theories and findings, training in the mechanisms for translating basic research into advancements in the treatment of cognitive disorders, and be well-prepared to employ a multidisciplinary research approach using skill sets encompassing the next generation of tools and technologies to address important questions in cognitive neurobiology. Our objective is to build on the remarkable successes that the C&CD Program has had in the previous 10 years and provide trainees enhanced training in experimental rigor, a better understanding of true translational research and a firm grasp of how to apply the next generation tools and technologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS061788-11
Application #
9491451
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Weigand, Letitia Alexis
Project Start
2008-07-01
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Neurosciences
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Paul, Jodi R; Munir, Hira A; van Groen, Thomas et al. (2018) Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease. Neurobiol Dis 114:194-200
Greathouse, Kelsey M; Boros, Benjamin D; Deslauriers, Josue F et al. (2018) Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity. Brain Struct Funct 223:4227-4241
Wadsworth, Heather M; Maximo, Jose O; Donnelly, Rebecca J et al. (2018) Action simulation and mirroring in children with autism spectrum disorders. Behav Brain Res 341:1-8
Wadsworth, Heather M; Maximo, Jose O; Lemelman, Amy R et al. (2017) The Action Imitation network and motor imitation in children and adolescents with autism. Neuroscience 343:147-156
Besing, Rachel C; Rogers, Courtney O; Paul, Jodi R et al. (2017) GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus 27:890-898
Laszczyk, Ann M; Fox-Quick, Stephanie; Vo, Hai T et al. (2017) Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss. Neurobiol Aging 59:41-54
Killion, Christy H; Mitchell, Elizabeth H; Duke, Corey G et al. (2017) Mechanical loading regulates organization of the actin cytoskeleton and column formation in postnatal growth plate. Mol Biol Cell 28:1862-1870
Cohen, Joshua L; Ata, Anooshah E; Jackson, Nateka L et al. (2017) Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats. Behav Brain Res 319:110-123
Duke, Corey G; Kennedy, Andrew J; Gavin, Cristin F et al. (2017) Experience-dependent epigenomic reorganization in the hippocampus. Learn Mem 24:278-288
Cohen, Joshua L; Jackson, Nateka L; Ballestas, Mary E et al. (2017) Amygdalar expression of the microRNA miR-101a and its target Ezh2 contribute to rodent anxiety-like behaviour. Eur J Neurosci 46:2241-2252

Showing the most recent 10 out of 60 publications