This is a revised renewal application for pre-doctoral training support for the Program in Neuroscience at the University of Maryland, Baltimore (UMB). This relatively young program (10 yrs) offers broad based multidisciplinary training in three areas of neuroscience: Behavioral/Systems, Cellular/Molecular and Developmental Neuroscience which reflects the research strengths of the faculty and are further codified in the following Research Focus Groups: Chemosensory, Drug Abuse, Neuroendocrinology, Neuroprotection, Pain, Schizophrenia, Synapses and Circuits and Clinical Neuroscience. The Training Program incorporates these areas by a combination of didactic courses, symposia, seminars and informal journal clubs. Participating faculty are based in clinical and basic science departments throughout the Schools of Medicine, Dentistry and Pharmacy with over 100 independent Pi's. Of those, we have chosen 56 as preceptors due to their outstanding training record, research credentials and history of funding. A strong administrative structure provides support and identity for students during the first 2 yrs and prior to matriculating into a laboratory. Implementation of a novel core curriculum provides vertical integration across three modules that advance from molecular genetics through structure and function to physiology. This first semester intensive course which includes extensive neuroscience curricula is complimented by a parallel one-credit course in Molecular Neuroscience &Biophysics. In the spring semester of the first year, students take broad-based Systems and Cognitive Neuroscience course and a wide array of electives, seminars, journal clubs, professor's rounds and three mandatory laboratory rotations. This combination provides excellent training for students from a variety of academic backgrounds. Previous trainees have moved on to postdoctoral positions or medical residencies. Many students have obtained independent funding from the NIH and other agencies. The Program provides coherence and accessibility to interdisciplinary interactions often difficult to obtain under traditional departmental, school-based units and has been recognized at the University level as a model for a recent reorganization that eliminated all departmentally based graduate programs. The predoctoral stipends requested in this application will be used to support outstanding students in their first two years prior to embarking full-time on laboratory research in one of the interdisciplinary research tracks

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-P (37))
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
Schools of Medicine
United States
Zip Code
White, Michael G; Panicker, Matthew; Mu, Chaoqi et al. (2018) Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control. Cell Rep 22:84-95
White, Michael G; Mathur, Brian N (2018) Claustrum circuit components for top-down input processing and cortical broadcast. Brain Struct Funct 223:3945-3958
White, Michael G; Mathur, Brian N (2018) Frontal cortical control of posterior sensory and association cortices through the claustrum. Brain Struct Funct 223:2999-3006
White, Michael G; Cody, Patrick A; Bubser, Michael et al. (2017) Cortical hierarchy governs rat claustrocortical circuit organization. J Comp Neurol 525:1347-1362
Girven, Kasey S; Sparta, Dennis R (2017) Probing Deep Brain Circuitry: New Advances in in Vivo Calcium Measurement Strategies. ACS Chem Neurosci 8:243-251
Kvarta, Mark D; Bradbrook, Keighly E; Dantrassy, Hannah M et al. (2015) Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses. J Neurophysiol 114:1713-24
Thompson, Scott M; Kallarackal, Angy J; Kvarta, Mark D et al. (2015) An excitatory synapse hypothesis of depression. Trends Neurosci 38:279-94
Park, Anthony; Hoffman, Kathleen; Keller, Asaf (2014) Roles of GABAA and GABAB receptors in regulating thalamic activity by the zona incerta: a computational study. J Neurophysiol 112:2580-96
Depireux, D A; Dobbins, H D; Marvit, P et al. (2012) Dynamics of phase-independent spectro-temporal tuning in primary auditory cortex of the awake ferret. Neuroscience 214:28-35
Dean, Shannon L; Knutson, Jessica F; Krebs-Kraft, Desiree L et al. (2012) Prostaglandin E2 is an endogenous modulator of cerebellar development and complex behavior during a sensitive postnatal period. Eur J Neurosci 35:1218-29