The essence of the proposal is the training of veterinarians to become intellectual leaders in comparative medicine. The primary goal is to impart the knowledge, methodological skills, and scholarly work habits which will enable trainees to conduct research to advance knowledge in biology and medicine. This is accomplished by a mentor relationship with an active scientist and full participation in a research project. The training activities are a continuation of a successful program which has been an integral part of the unit since it was established and benefits from an accumulation of training materials, a good reputation nation-wide which results in a large applicant pool, a high acceptance rate from individuals initially offered a position, and a dedicated and energetic faculty in comparative medicine. An interdepartmental program with an advisory committee composed of representatives from several departments to select trainees and provide direction is a major feature of the application. Strengths of the program include the medical school perspective and environment which ranks second in NIH extramural support, has 38 NIH-sponsored training grants, regularly sponsors a research integrity lecture series, a variety of resources, and mentors representing several disciplines in addition to the faculty in Comparative Medicine, e.g., Molecular Biotechnology, Immunology and Microbiology. Another feature of the proposal is the major revision of the currently funded program by moving the clinical training to a University-funded internship to be completed before entering the NIH-funded research training. A clerkship program for fourth-year veterinary students facilitates the recruitment of excellent trainees with national representation that includes participation from underrepresented minorities. Although the minority recruitment plan has been successful in the past, it has been revised to increase the size of the of the pool of minority candidates. Funding for six postdoctoral trainees is proposed for a period of three years each. The Regional Primate Research Center and transgenic laboratories especially noteworthy facilities associated with the training. This proposal offers an unusually rich opportunity to recruit and train the next generation of veterinary scientists in biomedical research, who are envisioned as becoming leaders in the field of comparative medicine while engaged in research, teaching, and service in an academic environment.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Institutional National Research Service Award (T32)
Project #
5T32RR007019-17
Application #
2714731
Study Section
Special Emphasis Panel (CM)
Project Start
1982-09-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Washington
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hagan, Catherine E; McDevitt, Ross A; Liu, Yusha et al. (2012) 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse 66:1024-34
Myshrall, Timothy D; Moore, Steven A; Ostendorf, Adam P et al. (2012) Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex. J Neuropathol Exp Neurol 71:1047-63
Lencioni, Karen C; Drivdahl, Rolf; Seamons, Audrey et al. (2011) Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancer. Comp Med 61:219-26
Hagan, Catherine E; Schenk, James O; Neumaier, John F (2011) The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse 65:1015-23
Hagan, Catherine E; Neumaier, John F; Schenk, James O (2010) Rotating disk electrode voltammetric measurements of serotonin transporter kinetics in synaptosomes. J Neurosci Methods 193:29-38
Lencioni, Karen Chase; Seamons, Audrey; Treuting, Piper M et al. (2008) Murine norovirus: an intercurrent variable in a mouse model of bacteria-induced inflammatory bowel disease. Comp Med 58:522-33
Torrence, Anne E; Brabb, Thea; Viney, Joanne L et al. (2008) Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. Inflamm Bowel Dis 14:480-90
Chou, Sonja T; Rabkin, Brian A; Dowling, Susan et al. (2004) Immunocompetent orthotopic isograft mouse model of ovarian cancer for high-intensity focused ultrasound (HIFU) treatment. Comp Med 54:645-51
Sanders, George E; Batts, William N; Winton, James R (2003) Susceptibility of zebrafish (Danio rerio) to a model pathogen, spring viremia of carp virus. Comp Med 53:514-21
Hankenson, F Claire; Johnston, Nancy A; Weigler, Benjamin J et al. (2003) Zoonoses of occupational health importance in contemporary laboratory animal research. Comp Med 53:579-601

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