TJL proposes to continue a formal training program in mammalian genetics to prepare graduate veterinarians for careers in independent biomedical research. Veterinarians have few opportunities to be trained in comparative pathology, molecular biology, and model development using inbred and genetically engineered laboratory mice. TJL is a unique nonprofit research institution that focuses on mice as animal models for genetic investigations into human diseases. The laboratory has a long history of training Ph.D.s, and more recently veterinarians, to correctly use these models in independent research. The investigators propose to continue the current postdoctoral training program for veterinarians, which include a Ph.D. option with the University of Maine. The program combines the talents of seven staff veterinarians (board certified in anatomic pathology, microbiology, or laboratory animal medicine) and a faculty selected from 33 staff research scientists to train these veterinarians to utilize the animal resources here. The investigators ask to maintain the three slots currently funded. This program is designed to meet the increasing demand for scientists in functional genomics research.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Watson, William T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Jackson Laboratory
Bar Harbor
United States
Zip Code
Pino, Steve; Brehm, Michael A; Covassin-Barberis, Laurence et al. (2010) Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol 602:105-17
Chase, Thomas H; Lyons, Bonnie L; Bronson, Roderick T et al. (2010) The mouse mutation ""thrombocytopenia and cardiomyopathy"" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood 115:1267-76
Pearson, T; Shultz, L D; Lief, J et al. (2008) A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51:1449-56
Seymour, R; Sundberg, J P; Hogenesch, H (2006) Abnormal lymphoid organ development in immunodeficient mutant mice. Vet Pathol 43:401-23
Maddatu, Terry P; Garvey, Sean M; Schroeder, David G et al. (2005) Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival. Hum Mol Genet 14:3179-89
Maddatu, Terry P; Garvey, Sean M; Schroeder, David G et al. (2004) Transgenic rescue of neurogenic atrophy in the nmd mouse reveals a role for Ighmbp2 in dilated cardiomyopathy. Hum Mol Genet 13:1105-15
Shultz, Leonard D; Banuelos, Scott; Lyons, Bonnie et al. (2003) NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation 76:1036-42
Lyons, Bonnie L; Lynes, Michael A; Burzenski, Lisa et al. (2003) Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient ""viable motheaten"" mice. Exp Hematol 31:234-43
Turgeon, Nicole A; Banuelos, Scott J; Shultz, Leonard D et al. (2003) Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice. Exp Biol Med (Maywood) 228:1096-104