EXCEED THE SPACE PROVIDED. This application is for the renewal of the 'Short-Term Research Training for Minority Students' program, based in the Division of Toxicological Sciences, Department of Environmental Health Sciences. The central goal of this program is to provide opportunities for qualified undergraduate minority and non-minority students to participate in laboratory research on the mechanisms of the adverse effects of environmental agents on human health. Secondary goals include: 1) increasing the awareness in these students of opportunities for training and careers in the fields of toxicology and environmental health; and 2) increasing the numbers of students aware of these career opportunities by accepting students from different colleges and universities across the country. The training faculty has primary or joint appointments in the Division/Department. Their research interests include: oxidative damage and stress (Culotta, Kensler, Singh, Trush, Yager, Zweier); cancer/carcinogenesis and hepatocyte growth regulation (Kensler, Trush, Yager); chemorpotection (Groopman, Kensler); molecular biomarkers of exposure and susceptibility (Groopman, Guilarte, Kensler, Risby, Strickland, Yager); hematopoeitic and immunotoxicology (Margolick, Rose, Trush), xenobiotic metabolism (Kensler, Trush, Yager), neurotoxicity (Dressier, Culotta, Guilarte, Jett, Lein), and in vitro toxicology (Goldberg, Trush, Yager). Applicants are recruited to this training program primarily through the Society of Toxicology (SOT). This summer research training program actually began in 1992. The application to NIEHS for support was submitted in 1995 and 1996 was the first year trainees were supported by the grant. Between 1992 and 1995 (inclusive) there were 7 summer research trainees, three of whom were minorities (Af. Am. [2], Hispanic [1]). In 1994, two were supported with the help of a special allocation of funds from the NIEHS through our 'Training Program in Environmental Health Sciences' training grant (T32 ES07141). Since 1996, the applicant pool has ranged from 11to 31. Each year three minority trainees have been supported on funds from this training grant, and one or two Caucasian trainees have been supported by research grants. Criteria for selection of students include academic performance (GPA> 3.0), completion of 2 years of college, interest in toxicology as relates to human health, letters of recommendation, and some prior lab experience through course work or research. In addition to working in the laboratory of their faculty sponsor, the minority students participate in the Johns Hopkins Medical Institutions Minority Summer Internship Program (MSIP). This program averages 20 students each year. The MSIP coordinates housing arrangements holds a welcoming reception and a weeklyjournal club where, over pizza and soft drinks, the students present papers under the supervision of participating faculty. Upon completion of their internships, trainees in our program receive certificates from the SOT, signed by its president and their faculty sponsor. They receive a letter and evaluation form from Dr. Yager, and each year they are contacted and asked to provide information on their progress through their academic careers and current status. PERFORMANCE SITE ========================================Section End===========================================

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
NRSA Short -Term Research Training (T35)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
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Johns Hopkins University
Public Health & Prev Medicine
Schools of Public Health
United States
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Rosenfeld, Leah; Culotta, Valeria C (2012) Phosphate disruption and metal toxicity in Saccharomyces cerevisiae: effects of RAD23 and the histone chaperone HPC2. Biochem Biophys Res Commun 418:414-9
Reddi, Amit R; Jensen, Laran T; Naranuntarat, Amornrat et al. (2009) The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection. Free Radic Biol Med 46:154-62
Leitch, Jeffry M; Yick, Priscilla J; Culotta, Valeria C (2009) The right to choose: multiple pathways for activating copper,zinc superoxide dismutase. J Biol Chem 284:24679-83
Howard, Angela S; Bucelli, Robert; Jett, David A et al. (2005) Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol Appl Pharmacol 207:112-24