This proposal describes a short-term, summer training programfor medical students focused on exposing students to career opportunities in basic and clinical research related to environmental health sciences. This application addresses 2 Specific Aims:
Aim 1 : To provide hands-on training in basic and clinical Environmental Health Sciences-based researchto medical students in a structured mentored environment.
Aim 2 : To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical Environmental Health Sciences-based research. The training program will include didactic instruction as well as a hands-on-research experience under the direction of a team of experienced basic and clinical researchscientists centered on a core of NIEHS-funded investigators and collaborating faculty. These faculty have long-standing success in mentoring medical and graduate students and post-doctoral fellows. Students who have completed at least one year of medical school will be eligible to apply for this 10-weektraining program. Trainees will be selected based upon their academic performance, letters of recommendation, and matching their research interests and career goals with suitable mentors. We have been successful in recruiting students from minority, rural, and economically disadvantaged backgrounds. The students will participate in an established 10-week didactic summer program: """"""""From Bench to Bedside: Introduction to Clinical Research"""""""", which included bioethics, as well as Environmental Health Sciences-specific seminars and journal clubs in basic and clinical research. Students will present posters of their research at the end of the program. The training program will begin with six trainees and increase to,ten trainees as the program.matures. Over the past 6 years the University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this short-term training program for medical students particularly timely. .
| Hardesty, Josiah E; Al-Eryani, Laila; Wahlang, Banrida et al. (2018) Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicol Sci 162:622-634 |
| Jin, Lexiao; Lipinski, Alexandra; Conklin, Daniel J (2018) A Simple Method for Normalization of Aortic Contractility. J Vasc Res 55:177-186 |
| Al-Eryani, Laila; Waigel, Sabine; Jala, Venkatakrishna et al. (2017) Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite. Toxicol Appl Pharmacol 331:130-134 |
| Hardesty, Josiah E; Wahlang, Banrida; Falkner, K Cameron et al. (2017) Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling. Xenobiotica 47:807-820 |
| McClain, Craig; Vatsalya, Vatsalya; Cave, Matthew (2017) Role of Zinc in the Development/Progression of Alcoholic Liver Disease. Curr Treat Options Gastroenterol 15:285-295 |
| Conklin, Daniel J; Haberzettl, Petra; Jagatheesan, Ganapathy et al. (2017) Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicol Appl Pharmacol 324:61-72 |
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| Cave, Matthew C; Clair, Heather B; Hardesty, Josiah E et al. (2016) Nuclear receptors and nonalcoholic fatty liver disease. Biochim Biophys Acta 1859:1083-1099 |
| Anders, Lisanne C; Lang, Anna L; Anwar-Mohamed, Anwar et al. (2016) Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice. Toxicol Sci 151:312-23 |
| Guardiola, John J; Beier, Juliane I; Falkner, K Cameron et al. (2016) Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome. Toxicol Appl Pharmacol 313:47-56 |
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