This NIEHS Short-Term Institutional Training Grant (5T35ES014559) application is to request support for 6 medical student trainees for the next 5 years. The overarching scientific theme of research that links the faculty to this T35 Training Grant is the common interest in research training of medical students in their laboratories in elucidating the health outcomes of exposure of obese individuals to various environmental or common chemicals in the environment. The faculty mentors involved come from the Department of Biochemistry & Molecular Biology (Klinge, Prough and Ramos), Department of Medicine, Division of Cardiovascular Medicine (Bhatnagar, Conklin, Prabhu, and Srivastava), Division of Pulmonary Medicine (Roman, Chair of Medicine), and Division of Gasteroenterology (Barve, Cave, Joshi-Barve, and McClain), Department of Pharmacology & Toxicology (Arteel, Hein and States), Department of Occupational and Environmental Health Sciences, School of Public Health and Information Sciences (Hoyle and Tollerud), and Molecular, Cellular & Craniofacial Biology, Birth Defects Research Center, School of Dentistry (Pisano). Most are funded from the NIEHS or grants that support research directly relevant to environmental health sciences. The NIEHS Center directed by Ken Ramos encourages faculty to compete for more NIEHS grants through career development and pilot project grants to the junior and senior faculty, respectively. The proposal contains two specific aims.
Specific aim 1 : To provide hands-on training in basic and clinical environmental health sciences- based research to medical students in a structured mentored environment.
Specific Aim 2 : To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical environmental health sciences-based research. The principal objectives of the Summer Environmental Health Sciences Research Training Program are to provide research experience for medical students and to stimulate interest among medical students in becoming clinical research scientists. Students who engage in research activities with faculty members will participate in projects germane to the field of environmental health and the health concerns of this country. The program includes didactic instruction (Syllabus for the Summer Environmental Health Sciences Research Training Seminar Series; Syllabus for the Bench to Bedside Course) as well as a hands-on- research experience directed by experienced scientists interested in environmental medicine.
Prough, Russell Allen Program Narrative: This NIEHS Short-Term Institutional Training Grant (5T35ES014559) application is to request annual support for 6 medical student trainees for a 12 week training experience for the next 5 years. The overarching scientific theme of research that links our faculty to this T35 Training Grant is the common interest in research training of Medical Students in our laboratories in elucidating the health outcomes of exposure of obese individuals to various environmental or common chemicals in the environment. We believe that this training experience will shape our medical student trainees to consider a career in areas of environmental medicine. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page
| Hardesty, Josiah E; Al-Eryani, Laila; Wahlang, Banrida et al. (2018) Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicol Sci 162:622-634 |
| Jin, Lexiao; Lipinski, Alexandra; Conklin, Daniel J (2018) A Simple Method for Normalization of Aortic Contractility. J Vasc Res 55:177-186 |
| Al-Eryani, Laila; Waigel, Sabine; Jala, Venkatakrishna et al. (2017) Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite. Toxicol Appl Pharmacol 331:130-134 |
| Hardesty, Josiah E; Wahlang, Banrida; Falkner, K Cameron et al. (2017) Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling. Xenobiotica 47:807-820 |
| McClain, Craig; Vatsalya, Vatsalya; Cave, Matthew (2017) Role of Zinc in the Development/Progression of Alcoholic Liver Disease. Curr Treat Options Gastroenterol 15:285-295 |
| Conklin, Daniel J; Haberzettl, Petra; Jagatheesan, Ganapathy et al. (2017) Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicol Appl Pharmacol 324:61-72 |
| Anders, Lisanne C; Yeo, Heegook; Kaelin, Brenna R et al. (2016) Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice. Toxicol Appl Pharmacol 311:34-41 |
| Cave, Matthew C; Clair, Heather B; Hardesty, Josiah E et al. (2016) Nuclear receptors and nonalcoholic fatty liver disease. Biochim Biophys Acta 1859:1083-1099 |
| Anders, Lisanne C; Lang, Anna L; Anwar-Mohamed, Anwar et al. (2016) Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice. Toxicol Sci 151:312-23 |
| Guardiola, John J; Beier, Juliane I; Falkner, K Cameron et al. (2016) Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome. Toxicol Appl Pharmacol 313:47-56 |
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