Abstract

This application provides continuing data management support and statistical support for the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Data base support is required for the CERAD data collection, one of the largest active longitudinal data bases of Alzheimer's disease (AD), with more than 1,200 cases and 470 healthy elderly controls. This large data base contains annual demographic, clinical, neurological, and behavioral data, and, ultimately, neuropathological data, for probable and possible AD cases enrolled since 1987. This case material is being expanded as annual follow-up and autopsy data accumulates. Statistical support will encompass four general areas: 1) analyzing, interpreting, and publishing the wealth of baseline and longitudinal information accumulating in the CERAD data base; 2) development, description, and application of statistical methods for analyzing data on AD; longitudinal analyses and survival analytic methods will be a special concern; 3) extraction and reporting of information from CERAD relevant to the design and analysis of clinical trials in AD; power calculation and sample size requirements based on different proposed study designs will be estimated and compared using the CERAD data base.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG006790-10
Application #
6295455
Study Section
Project Start
1996-09-15
Project End
2000-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Fillenbaum, Gerda G; Burchett, Bruce M; Unverzagt, Frederick W et al. (2011) Norms for CERAD constructional praxis recall. Clin Neuropsychol 25:1345-58
Fillenbaum, Gerda G; van Belle, Gerald; Morris, John C et al. (2008) Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years. Alzheimers Dement 4:96-109
Klatte, Emily T; Scharre, Douglas W; Nagaraja, Haikady N et al. (2003) Combination therapy of donepezil and vitamin E in Alzheimer disease. Alzheimer Dis Assoc Disord 17:113-6
Taylor Jr, Donald H; Fillenbaum, Gerda G; Ezell, Michael E (2002) The accuracy of medicare claims data in identifying Alzheimer's disease. J Clin Epidemiol 55:929-37
Fillenbaum, G; Heyman, A; Peterson, B L et al. (2001) Use and cost of outpatient visits of AD patients: CERAD XXII. Neurology 56:1706-11
Fillenbaum, G; Heyman, A; Peterson, B L et al. (2001) Use and cost of hospitalization of patients with AD by stage and living arrangement: CERAD XXI. Neurology 56:201-6
Fillenbaum, G; Heyman, A; Peterson, B et al. (2000) Frequency and duration of hospitalization of patients with AD based on Medicare data: CERAD XX. Neurology 54:740-3
Koss, E; Peterson, B; Fillenbaum, G G (1999) Determinants of attrition in a natural history study of Alzheimer disease. Alzheimer Dis Assoc Disord 13:209-15
Kuhl, D E; Koeppe, R A; Minoshima, S et al. (1999) In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology 52:691-9
Clark, C M; Sheppard, L; Fillenbaum, G G et al. (1999) Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease. Arch Neurol 56:857-62

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