This application is to continue the Study of Women's Health Across the Nation (SWAN) for a second five year funding cycle. SWAN II is poised to contribute substantive new knowledge on the menopause transition through its prospective design, multi-ethnic/racial composition, representativeness of defined populations, and comprehensive measurement and power. No other recent or ongoing study is in a position to respond to the breadth of identified gaps in scientific knowledge on the menopause transition, either because sample sizes or follow-up data are insufficient, the multidisciplinary data are lacking or are restrictive, or because the samples are homogeneous. This application serves as the primary scientific application for SWAN. There are also companion applications being submitted by the Coordinating Center (NERI) and the Central Endocrine Laboratory (CLASS). This executive summary serves as the overall summary and progress report for SWAN I and as an introduction to the four substantive project applications which follow. The four project applications each provide a detailed proposal to address one of four major objectives originally identified in the RFA (number AG-94-002), from which the Study of Women's Health Across the Nation (SWAN I), was funded in September, 1994, by the National Institute on Aging with support from the National Institute of Nursing Research and the Office of Research on Women's Health. The objectives from the original RFA and the project applications which follow this executive summary are: 1) To collect and analyze data on demographics, health and social characteristics, race/ethnicity, reproductive history, pre-existing illness, physical activity (includes activity limitations), health practices"""""""" (includes diet, smoking, use of OTC) as potential predictor variables and to describe the multiethnic community-based samples of mid-life women. (Risk Factor Project); 2) To elucidate factors that differentiate symptomatic from asymptomatic women during the [menopausal] transition. (Risk Factor Project); 3) To identify and utilize appropriate markers of ovarian aging or aging of the ovarian-hypothalamo-pituitary axis and relate these markers to alterations in menstrual characteristics as women approach and traverse menopause. (Ovarian Aging Project); 4) To elucidate factors that differentiate women most susceptible to long-term pathophysiological consequences of ovarian hormone deficiency from those who are protected. (Cardiovascular Project and Bone Project)

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG012554-10
Application #
6624592
Study Section
Special Emphasis Panel (ZAG1-BJB-8 (O8))
Program Officer
Sherman, Sherry
Project Start
1994-09-30
Project End
2004-04-30
Budget Start
2002-12-01
Budget End
2004-04-30
Support Year
10
Fiscal Year
2003
Total Cost
$483,007
Indirect Cost
Name
University of California Davis
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Allshouse, Amanda; Pavlovic, Jelena; Santoro, Nanette (2018) Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms. Obstet Gynecol Clin North Am 45:613-628
Hanley, Carrie; Shields, Kelly J; Matthews, Karen A et al. (2018) Associations of cardiovascular fat radiodensity and vascular calcification in midlife women: The SWAN cardiovascular fat ancillary study. Atherosclerosis 279:114-121
Chyu, Laura; Upchurch, Dawn M (2018) A Longitudinal Analysis of Allostatic Load among a Multi-Ethnic Sample of Midlife Women: Findings from the Study of Women's Health Across the Nation. Womens Health Issues 28:258-266
Hanley, Carrie; Matthews, Karen A; Brooks, Maria M et al. (2018) Cardiovascular fat in women at midlife: effects of race, overall adiposity, and central adiposity. The SWAN Cardiovascular Fat Study. Menopause 25:38-45
Chung, Hsin-Fang; Pandeya, Nirmala; Dobson, Annette J et al. (2018) The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium. Psychol Med 48:2550-2561
Dugan, Sheila A; Gabriel, Kelley Pettee; Lange-Maia, Brittney S et al. (2018) Physical Activity and Physical Function: Moving and Aging. Obstet Gynecol Clin North Am 45:723-736
B├ęcares, Laia; Zhang, Nan (2018) Perceived Interpersonal Discrimination and Older Women's Mental Health: Accumulation Across Domains, Attributions, and Time. Am J Epidemiol 187:924-932
Everson-Rose, Susan A; Clark, Cari J; Wang, Qi et al. (2018) Depressive symptoms and adipokines in women: Study of women's health across the nation. Psychoneuroendocrinology 97:20-27
Hedgeman, Elizabeth; Hasson, Rebecca E; Karvonen-Gutierrez, Carrie A et al. (2018) Perceived stress across the midlife: longitudinal changes among a diverse sample of women, the Study of Women's health Across the Nation (SWAN). Womens Midlife Health 4:
Waetjen, L Elaine; Crawford, Sybil L; Chang, Po-Yin et al. (2018) Factors associated with developing vaginal dryness symptoms in women transitioning through menopause: a longitudinal study. Menopause 25:1094-1104

Showing the most recent 10 out of 416 publications