This application is for the competing continuation of the National Alzheimer Coordinating Center (NACC) [U01 AG016976] first funded in 1999 in response to an RFA issued by the National Institute on Aging (NIA) and subsequently renewed in 2004. The present application is for the period of July 1, 2009 through June 30, 2014. Consistent with the original RFA and the accrued, developed intent of the NIA and the Alzheimer Disease Centers (ADC) program during the previous funding cycles, the mission of the NACC is to develop and maintain a common/standardized database, accounting for the enrollment at all ADCs, and to facilitate collaborative research among the ADC's, based directly on the database as well as through independent initiatives of ADC investigators. To that end, NACC provides for competitive, peer reviewed funding of investigator initiated collaborative projects and for junior-investigator secondary data analysis projects based directly on the database. NACC works closely with ADCs providing data management, statistical and research consulting and conducts its own methodological and empirical scientific investigations In addition to these aspects NACC also has a variety of administrative responsibilities for interactions and communications across ADCs and with NIA. Specifically: To maintain and further develop the NACC database and facilitate its use for research;To continue and build upon the Uniform Data Set (UDS) data quality assurance and quality control procedures already in place;To promote collaborative research among the ADCs through research funding and technical support;To develop new methodological tools and approaches relevant to research on AD and related disorders;To conduct descriptive and analytic studies of specific content areas from the NACC database;To perform NACC's NIA-required administrative functions: provide logistical support for directors'and core leaders'meetings, interface with NIA initiative groups;distribute funds in support of NACC data collection effort and collaborative projects;and facilitate inter-ADC communication.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG016976-14
Application #
8288090
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J4))
Program Officer
Phelps, Creighton H
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$3,293,315
Indirect Cost
$404,569
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Smith, Eric E; Muzikansky, Alona; McCreary, Cheryl R et al. (2018) Impaired memory is more closely associated with brain beta-amyloid than leukoaraiosis in hypertensive patients with cognitive symptoms. PLoS One 13:e0191345
Blue, E E; Yu, C-E; Thornton, T A et al. (2018) Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease. Genes Brain Behav 17:e12429
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Lobach, Iryna; Sampson, Joshua; Alekseyenko, Alexander et al. (2018) Case-control studies of gene-environment interactions. When a case might not be the case. PLoS One 13:e0201140
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Li, Xinzhong; Wang, Haiyan; Long, Jintao et al. (2018) Systematic Analysis and Biomarker Study for Alzheimer's Disease. Sci Rep 8:17394
Gangishetti, Umesh; Christina Howell, J; Perrin, Richard J et al. (2018) Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease. Alzheimers Res Ther 10:98
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25

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