Exceptional Survival in Danish and Italian Families We propose research requested in the NIA RFA on """"""""Exceptional Survival in Families"""""""" (ESF). In particular, we plan to gather questionnaire and physiological data on 1000 pairs (half in Denmark and half in Italy) of living nonagenarian and centenariala sibs and their living brothers, sisters and children. We will also gather information on the lifespans of the sibs' parents. We will validate ages by examining birth certificates and, when appropriate, marriage certificates and death certificates. We will collaborate with other ESF Study Centers to develop appropriate questionnaires and survey procedures. We will develop powerful, appropriate models and methods of statistical/demographic analysis to study the data in collaboration with other ESF Study Centers.
| Marron, Megan M; Singh, Jatinder; Boudreau, Robert M et al. (2018) A novel healthy blood pressure phenotype in the Long Life Family Study. J Hypertens 36:43-53 |
| Arbeeva, Liubov S; Hanson, Heidi A; Arbeev, Konstantin G et al. (2018) How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database. Front Public Health 6:277 |
| Pedersen, Jacob K; Elo, Irma T; Schupf, Nicole et al. (2017) The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci 72:109-114 |
| Fagan, Erin; Sun, Fangui; Bae, Harold et al. (2017) Telomere length is longer in women with late maternal age. Menopause 24:497-501 |
| Singh, Jatinder; Minster, Ryan L; Schupf, Nicole et al. (2017) Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. J Gerontol A Biol Sci Med Sci 72:1411-1416 |
| Barral, Sandra; Singh, Jatinder; Fagan, Erin et al. (2017) Age-Related Biomarkers in LLFS Families With Exceptional Cognitive Abilities. J Gerontol A Biol Sci Med Sci 72:1683-1688 |
| Sebastiani, Paola; Thyagarajan, Bharat; Sun, Fangui et al. (2017) Biomarker signatures of aging. Aging Cell 16:329-338 |
| Sebastiani, Paola; Gurinovich, Anastasia; Bae, Harold et al. (2017) Assortative Mating by Ethnicity in Longevous Families. Front Genet 8:186 |
| Yashin, Anatoliy I; Zhbannikov, Ilya; Arbeeva, Liubov et al. (2016) Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures. Front Genet 7:188 |
| Sebastiani, Paola; Thyagarajan, Bharat; Sun, Fangui et al. (2016) Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc 64:e189-e194 |
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