The Biostatistics Core (Core C) will bridge the transition from the DIAN database stored and managed bythe Informatics Core (Core H) to the analyses of the longitudinal data within, between, and among thevarious data domains, the latter of which serves as the primary responsibility of the Core. Specifically theBiostatistics Core will: (1) oversee the statistical quality control of data for the study and produceappropriately de-identified and statistically analyzable datasets for distribution/analysis; (2) lead the statisticaldata analyses and collaborate in report preparation for all Cores and projects, and consult on the design ofall projects and on the application of appropriate statistical and methodological techniques; (3) develop andimplement appropriate statistical models for longitudinal changes in potential markers and use these modelsto test the statistical hypotheses about the preclinical changes of AD and about the temporal difference onpreclinical changes of AD among various markers, and (4) serve as an advisory group for other researchersinterested in using the DIAN database for additional analyses. The Biostatistics core will achieve thesespecific aims through extensive interactions and collaborations with all other components of DIAN.
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