Abstract

In response to RFA AI-00-015, the New Jersey Pediatric AIDS Consortium (NJ-PAC) is submitting this application to continue participation as a Pediatric AIDS Clinical Trials Unit (PACTU) affiliated with the Coordinating and Operations Center (CORC), led by Dr. Stephen Spector, to advance the research agenda of the PACTG. NJ-PAC investigators and resources offer a combination of experienced leadership, scientific contributions, and an extensive patient base in the context of a strong clinical infrastructure. Through this collaboration, NJ-PAC?s obstetrical, pediatric, and adolescent investigators will continue to enroll pregnant women, infants, children and adolescents into high priority Phase I, II and III clinical trials, with co-enrollment of these patients into long term outcome studies. This application details comprehensive plans that address all aspects of the future PACTG research agenda: Perinatal, Primary Therapy, Adolescence, Complications of HIV, and Immunology/Immune-Based Therapy. In addition, NJ-PAC and its investigators are active collaborators with national and international groups. The experience and contributions of our NJ-PAC investigators during the last four-year funding cycle and the large, diverse HIV-infected populations within the NJ-PAC service area, position NJ-PAC as a critical unit for the future success of the PACTG research agenda.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI025883-16
Application #
6732676
Study Section
Special Emphasis Panel (ZAI1-PSS-A (J1))
Program Officer
Matula, Margaret A
Project Start
1987-09-30
Project End
2007-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
16
Fiscal Year
2004
Total Cost
$1,223,366
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Pediatrics
Type
Schools of Medicine
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107

  Publications

Cohn, Susan E; Umbleja, Triin; Mrus, Joseph et al. (2008) Prior illicit drug use and missed prenatal vitamins predict nonadherence to antiretroviral therapy in pregnancy: adherence analysis A5084. AIDS Patient Care STDS 22:29-40
McComsey, Grace A; Kang, Minhee; Ross, Allison C et al. (2008) Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy. HIV Clin Trials 9:126-36
Hitti, Jane; Andersen, Janet; McComsey, Grace et al. (2007) Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol 196:331.e1-7
Livingston, Elizabeth G; Cohn, Susan E; Yang, Yang et al. (2007) Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy. Obstet Gynecol 110:391-7
Palumbo, Paul; Wu, Hulin; Chadwick, Ellen et al. (2007) Virologic response to potent antiretroviral therapy and modeling of HIV dynamics in early pediatric infection. J Infect Dis 196:23-9
Al-Khan, Anthony; Colon, Jose; Palta, Vidya et al. (2003) Assisted reproductive technology for men and women infected with human immunodeficiency virus type 1. Clin Infect Dis 36:195-200
Eshleman, S H; Krogstad, P; Jackson, J B et al. (2001) Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). J Infect Dis 183:1732-8
Buchacz, K; Cervia, J S; Lindsey, J C et al. (2001) Impact of protease inhibitor-containing combination antiretroviral therapies on height and weight growth in HIV-infected children. Pediatrics 108:E72
McSherry, G D; Shapiro, D E; Coombs, R W et al. (1999) The effects of zidovudine in the subset of infants infected with human immunodeficiency virus type-1 (Pediatric AIDS Clinical Trials Group Protocol 076). J Pediatr 134:717-24
McSherry, G D (1996) Human immunodeficiency-virus-related pulmonary infections in children. Semin Respir Infect 11:173-83

Showing the most recent 10 out of 17 publications