We propose to establish a center with laboratory, clinical, research, and education components in order to improve our ability to diagnose, treat, and prevent HIV infection. We propose to develop a set of core laboratories and facilities to 1) provide special assays of importance for measuring immunological, virological, and serological aspects of HIV infection, 2) develop a pharmacokinetics laboratory to follow levels of anti-HIV therapeutic agents, and 3) establish the necessary computer and biostatistics facilities for evaluation of the data. The clinical studies are intended to 1) analyze the diversity and significance of neuropsychiatric abnormalities at all stages of HIV infection, 2) evaluate anti-HIV therapeutic agents in a broad group of symptomatic infected patients, and 3) develop improved treatment approaches to AIDS-associated opportunistic infections such as cryptococcal meningitis and disseminated cytomegalovirus infection. The specific goals for the basic research studies are to 1) develop and apply improved measures of virus load in clinical samples, 2) examine quantitative and qualitative abnormalities of T and B-lymphocytes and monocytes at all stages of HIV infection, 3) use murine models of cryptococcal infection for the development of new therapeutic approaches, and 4) study the epidemiology of HIV and related viruses including HTLV-L, HTLV- II, and HTLV-IV in a high risk population in our community. We plan to expand and evaluate our presently developed educational programs which have been directed to gay and drug-abusing individuals, as well as other individuals, including school teacher, high school and college students, and physicians, nurses, other medical personnel, as well as the general population in smaller communities within several hundred miles of the St. Louis area. The latter activities are especially important in prevention of spread of this virus in our community, which has a relatively low overall prevalence of infection.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Cade, W Todd; Singh, Gautam K; Holland, Mark R et al. (2015) Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV taking antiretroviral therapy: a cross-sectional pilot study. Clin Nutr ESPEN 10:e140-e146
Clifford, David B (2015) Neurological immune reconstitution inflammatory response: riding the tide of immune recovery. Curr Opin Neurol 28:295-301
Kempen, John H; Sugar, Elizabeth A; Varma, Rohit et al. (2014) Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections. Ophthalmology 121:2317-24
Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6
Zhang, Xinyan; Tierney, Camlin; Albrecht, Mary et al. (2013) Discordant associations between SLCO1B1 521T?C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. Ther Drug Monit 35:209-16
Kempen, John H; Sugar, Elizabeth A; Lyon, Alice T et al. (2012) Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome. Ophthalmology 119:2343-50
Sacktor, N; Miyahara, S; Deng, L et al. (2011) Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 77:1135-42
Ribaudo, Heather J; Benson, Constance A; Zheng, Yu et al. (2011) No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT. Clin Infect Dis 52:929-40
Shacham, Enbal; Hoffer, Lee; Overton, Edgar Turner (2011) Perceptions of alcohol risk among individuals living with HIV. AIDS Care 23:107-12
Puhan, Milo A; Ahuja, Alka; Van Natta, Mark L et al. (2011) Interviewer versus self-administered health-related quality of life questionnaires - does it matter? Health Qual Life Outcomes 9:30

Showing the most recent 10 out of 190 publications