Abstract

The overall goal is to conceptualize, invent and evaluate new agents against HIV, the causative agent in AIDS. The approaches will include immunological, biological and synthetic studies and hence will be comprehensive in nature.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI025993-04
Application #
3547021
Study Section
Special Emphasis Panel (SRC (49))
Project Start
1987-09-30
Project End
1992-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Morrison, S A; Pearson, S L; Steigbigel, R T (1998) Anti-F(ab')2 antibody in HIV type 1 infection: relationship to hypergammaglobulinemia and to antibody specific to the V3 loop region of glycoprotein 120. AIDS Res Hum Retroviruses 14:491-8
Moorjani, H; Craddock, B P; Morrison, S A et al. (1996) Impairment of phagosome-lysosome fusion in HIV-1-infected macrophages. J Acquir Immune Defic Syndr Hum Retrovirol 13:18-22
Handley, M A; Steigbigel, R T; Morrison, S A (1996) A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages. J Virol 70:4451-6
Maruenda, H; Johnson, F (1995) Design and synthesis of novel inhibitors of HIV-1 reverse transcriptase. J Med Chem 38:2145-51
Tyagi, S C; Simon, S R; Carter, C A (1994) Effect of pH and nonphysiological salt concentrations on human immunodeficiency virus-1 protease dimerization. Biochem Cell Biol 72:175-81
Zybarth, G; Krausslich, H G; Partin, K et al. (1994) Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain. J Virol 68:240-50
Carter, C; Zybarth, G (1994) Processing of retroviral Gag polyproteins: an in vitro approach. Methods Enzymol 241:227-53
Ehrlich, L S; Agresta, B E; Gelfand, C A et al. (1994) Spectral analysis and tryptic susceptibility as probes of HIV-1 capsid protein structure. Virology 204:515-25
Suzuki, K; Craddock, B P; Kano, T et al. (1993) Colorimetric reverse transcriptase assay for HIV-1. J Virol Methods 41:21-8
Tyagi, S C; Carter, C A (1992) Continuous assay of the hydrolytic activity of human immunodeficiency virus-1 protease. Anal Biochem 200:143-8

Showing the most recent 10 out of 23 publications