Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI026077-04
Application #
3547096
Study Section
Special Emphasis Panel (SRC (21))
Project Start
1988-04-01
Project End
1991-06-30
Budget Start
1991-04-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Sharma, Mayuri; Coen, Donald M (2014) Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress. J Virol 88:10982-5
Strang, Blair L; Boulant, Steeve; Kirchhausen, Tomas et al. (2012) Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. MBio 3:
Strang, Blair L; Boulant, Steeve; Coen, Donald M (2010) Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol 84:1771-84
Gentry, Brian G; Kamil, Jeremy P; Coen, Donald M et al. (2010) Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother 54:3093-8
Baltz, Jennifer L; Filman, David J; Ciustea, Mihai et al. (2009) The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol 83:12215-28
Jiang, Changying; Komazin-Meredith, Gloria; Tian, Wang et al. (2009) Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. J Virol 83:7573-80
Strang, Blair L; Sinigalia, Elisa; Silva, Laurie A et al. (2009) Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. J Virol 83:7581-9
Komazin-Meredith, Gloria; Santos, Webster L; Filman, David J et al. (2008) The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem 283:6154-61
Hume, Adam J; Finkel, Jonathan S; Kamil, Jeremy P et al. (2008) Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science 320:797-9
Loregian, Arianna; Coen, Donald M (2006) Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem Biol 13:191-200

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