The objectives of UCSD Pediatric ACTU are to identify promising new treatments for persons infected with HIV and to bring these agents as expeditiously as possible to clinical trials within the ACTG with the goal of improving treatments for HIV infection and its associated infections, and preventing maternal-infant transmission. The UCSD Pediatric ACTU is an integrated program which from its inception has incorporated core laboratory support and developmental laboratory research with clinical investigation. The clinical and laboratory cores of Neuropsychology Retrovirology (9001) will continue to provide protocol required core clinical and laboratory support for ACTG-sponsored clinical studies. Additionally, several developmental programs will enhance our ability to advance the treatment of pregnant women and children infected with HIV. These include: (1) A Developmental Retrovirology Program (0002) that will develop dependable, standardized and biologically meaningful assays of virus replication to assess disease risk and effective interventions. (2) A Developmental Immunology Program (0003) that addresses the need for immunological disease markers in children by measuring cytokine expression and cell proliferation in immune cells and by correlating these parameters with HIV expression and cell proliferation in immune cells. The UCSD Pediatric ACTU has already established an integrated program of core clinical research, core laboratory support and developmental research. We have developed a diverse and cohesive program which draws upon the expertise and excellence of clinical investigators, core laboratory support and developmental research. The participation of each of these components of our program will contribute to the continued success of our ACTU.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI027563-12
Application #
2882152
Study Section
Special Emphasis Panel (ZAI1-OTP-A (01))
Program Officer
Batzold, Frederick
Project Start
1988-09-30
Project End
2001-02-28
Budget Start
1999-03-01
Budget End
2000-02-29
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Saitoh, Akihiko; Capparelli, Edmund; Aweeka, Francesca et al. (2010) CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr 54:285-9
Saitoh, Akihiko; Foca, Marc; Viani, Rolando M et al. (2008) Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection. Pediatrics 121:e513-21
Saitoh, Akihiko; Haas, Richard H; Naviaux, Robert K et al. (2008) Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells. Antimicrob Agents Chemother 52:2825-30
Hitti, Jane; Andersen, Janet; McComsey, Grace et al. (2007) Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol 196:331.e1-7
Saitoh, Akihiko; Sarles, Elizabeth; Capparelli, Edmund et al. (2007) CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS 21:2191-9
Singh, K K; Spector, S A (2007) Fidelity of whole-genome amplification of blood spot DNA for HLA typing and SNP analyses. Clin Genet 72:156-9
Saitoh, Akihiko; Fletcher, Courtney V; Brundage, Richard et al. (2007) Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism. J Acquir Immune Defic Syndr 45:280-5
Seage 3rd, George R; Buchacz, Kate; Weinberg, Geoffrey A et al. (2006) The Pediatric AIDS Severity Score (PASS): a multidimensional AIDS-severity adjustment for pediatric HIV infection. J Acquir Immune Defic Syndr 43:603-10
Patel, Kunjal; Weinberg, Geoffrey A; Buchacz, Kate et al. (2006) Simple Pediatric AIDS Severity Score (PASS): a pediatric severity score for resource-limited settings. J Acquir Immune Defic Syndr 43:611-7
Saitoh, Akihiko; Singh, Kumud K; Sandall, Sharsti et al. (2006) Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy. J Allergy Clin Immunol 117:909-15

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