The BROAD OBJECTIVE of the DEVELOPMENTAL PHARMACOLOGY RESEARCH PROJECT is to further utilize THE POPULATION PHARMACOKINETIC PROGRAM and DATABASE of the PHARMACOLOGY CORE LABORATORY to examine the PHARMACODYNAMICS of AIDS ANTIRETROVIRALS and OTHER ANTIVIRALS against VIRAL O.I.s in AIDS patients.
The SPECIFIC AIMS of DEVELOPMENTAL PHARMACOLOGY are: 1. To further INTRODUCE and to IMPLEMENT POPULATION PHARMACOKINETIC studies in ONGOING and FUTURE ACTG DRUG TRIALS. 2. To assess PHARMACODYNAMICS of ANTIRETROVIRALS, and other ANTIVIRAL COMPOUNDS, in ACTG PATIENT POPULATIONS, through PROSPECTIVE and RETROSPECTIVE studies, using the NONMEM PROGRAM, or other STATISTICAL PROGRAMS.

Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Beliakova-Bethell, Nadejda; Hezareh, Marjan; Wong, Joseph K et al. (2017) Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology 508:127-133
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Krishnan, Supriya; Schouten, Jeffrey T; Atkinson, Benjamin et al. (2015) Changes in metabolic syndrome status after initiation of antiretroviral therapy. J Acquir Immune Defic Syndr 68:73-80
Massanella, Marta; Gianella, Sara; Schrier, Rachel et al. (2015) Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy. Sci Rep 5:13179
Gianella, Sara; Smith, Davey M; Daar, Eric S et al. (2015) Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men. PLoS One 10:e0130410

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