Abstract

Bullous pemphigoid is an acquired autoimmune dermatitis, in which mast cells have been implicated as important effector cells. Like the physical allergies and mastocytoses, bullous pemphigoid provides a unique setting for assessing the contribution of mast cells to the pathophysiologic events of an immunologically-mediated disease. To achieve these goals, we plan to biopsy lesions in patients with bullous pemphigoid. In the tissues we will determine mast cell distribution and how mast cell phenotype and/or degranulation-regranulation characteristics correlate with stage of lesion development, associated lymphocytes, associated eosinophils, and state of endothelial activation. The findings will provide insight into the specific role of mast cells in mediating the pathophysiologic events. Controls will include mast cells in normal tissues and clinically similar dermatitides. Findings will be quantitated and apparent differences tested for statistical significance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI031599-02
Application #
3791699
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Ohta, Shin; Imamura, Mitsuru; Xing, Wei et al. (2013) Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol 190:5927-38
Lundequist, Anders; Boyce, Joshua A (2011) LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1? release. PLoS One 6:e18192
Saino, Hiromichi; Ukita, Yoko; Ago, Hideo et al. (2011) The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem 286:16392-401
Laidlaw, Tanya M; Steinke, John W; Tinana, Adrienne M et al. (2011) Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcýýRI. J Allergy Clin Immunol 127:815-22.e1-5
Giannattasio, Giorgio; Ohta, Shin; Boyce, Joshua R et al. (2011) The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J Immunol 187:1486-95
Giannattasio, Giorgio; Fujioka, Daisuke; Xing, Wei et al. (2010) Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol 185:4430-8
Lundequist, Anders; Nallamshetty, Samridhi N; Xing, Wei et al. (2010) Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol 184:433-41
Barrett, Nora A; Maekawa, Akiko; Rahman, Opu M et al. (2009) Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 182:1119-28
Jones, Tatiana G; Hallgren, Jenny; Humbles, Alison et al. (2009) Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183:5251-60
Jiang, Yongfeng; Borrelli, Laura; Bacskai, Brian J et al. (2009) P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol 182:1129-37

Showing the most recent 10 out of 14 publications