The Women and Infants Transmission Study (WITS) is a national, multi-center, longitudinal observational cohort study ofHIV-1 infected pregnant women and their infants that has been enrolling, patients for the last decade. The overall goal of the study is to understand HIV -I infection in pregnant women and in infants, children and adolescents, and the course, response, challenges, and side effects of antiretroviral therapy. This application is the WITS IV Leadership and Research Agenda application, which will be supported by six separate clinical site applications. The Leadership and Research Agenda will define the study aims, justification, study structure, and study approach for WITS IV. The Principle Investigator of the application will chair the WITS Executive Committee, the governing body of WITS.
The Specific Aims for WITS IV include I. To define the natural history of HIV-l infection in infants, children, and adolescents in an era of anti-retroviral therapy (ART); 2. To determine the immediate and late effects of exposure to ART in uninfected fetuses, infants, children, and adolescents; 3. To define the natural history of HIV-I infected women enrolled during pregnancy in the era of ART; 4. To examine the relationships between adherence to ART medication, emergence of HIV-I resistant to ART, and the clinical and treatment outcome in pediatric patients and their mothers; 5. To define the pathogenesis and natural history of HCV and HIV-l/HCV co-infection in HIV-l infected pregnant women, to identify a cohort of women with new HCV infection, and to examine the factors responsible for the transmission of HCV from mothers to their infants. This application will build on the studies done in WITS 1-111 to examine the changing landscape of HIV-l infection in eras of increasing potency of ART. It will contribute to an in-depth understanding of the new era of perinatal HIV-l infection and the consequence and challenges of therapy to prevent and treat the infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034841-10
Application #
6534036
Study Section
Special Emphasis Panel (ZAI1-GLM-A (M2))
Program Officer
Ryan, Kevin W
Project Start
1993-09-01
Project End
2006-06-30
Budget Start
2002-09-01
Budget End
2003-06-30
Support Year
10
Fiscal Year
2002
Total Cost
$985,741
Indirect Cost
Name
University of Illinois at Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Ouyang, David W; Brogly, Susan B; Lu, Ming et al. (2010) Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals. AIDS 24:109-14
Paredes, Roger; Cheng, Irene; Kuritzkes, Daniel R et al. (2010) Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS 24:45-53
Mekmullica, Jutarat; Brouwers, Pim; Charurat, Manhattan et al. (2009) Early immunological predictors of neurodevelopmental outcomes in HIV-infected children. Clin Infect Dis 48:338-46
Watts, D H; Lu, M; Thompson, B et al. (2009) Treatment interruption after pregnancy: effects on disease progression and laboratory findings. Infect Dis Obstet Gynecol 2009:456717
Ouyang, David W; Shapiro, David E; Lu, Ming et al. (2009) Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure. AIDS 23:2425-30
Aldrovandi, Grace M; Chu, Clara; Shearer, William T et al. (2009) Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics 124:e1189-97
Dowd, Kimberly A; Hershow, Ronald C; Yawetz, Sigal et al. (2008) Maternal neutralizing antibody and transmission of hepatitis C virus to infants. J Infect Dis 198:1651-5
Pahwa, Savita; Read, Jennifer S; Yin, Wanrong et al. (2008) CD4+/CD8+ T cell ratio for diagnosis of HIV-1 infection in infants: Women and Infants Transmission Study. Pediatrics 122:331-9
Chen, Katherine T; Tuomala, Ruth E; Chu, Clara et al. (2008) No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission. Am J Obstet Gynecol 198:399.e1-5
Mellins, C A; Chu, C; Malee, K et al. (2008) Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women. AIDS Care 20:958-68

Showing the most recent 10 out of 48 publications