Abstract

The Women and Infants Transmission Study I at the University of Puerto Rico Site has finished successfully its projected goals for its first funding cycle. Accomplishments during this period include: a total accrual of 157 pregnant, 47 non-pregnant HIV infected women and 115 infants. During the years 1990-92 a total of 13,026 pregnant women were tested for HIV. Our proposal includes an expansion of our catchment area. Universal offering of prenatal screening will be expanded from the original Metropolitan Health Region to two additional high-prevalence health regions in Puerto Rico. Unification of all proposed WITS II clinical activities, as well as those of the Adult and Pediatric ACTU in one center, the Women and Children HIV Care Center will facilitate enrollment, referral and coordination of the multiple and much needed services our families require.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034858-03
Application #
2070069
Study Section
Special Emphasis Panel (SRC (90))
Project Start
1993-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Puerto Rico Med Sciences
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936

  Publications

Ouyang, David W; Brogly, Susan B; Lu, Ming et al. (2010) Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals. AIDS 24:109-14
Paredes, Roger; Cheng, Irene; Kuritzkes, Daniel R et al. (2010) Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS 24:45-53
Mekmullica, Jutarat; Brouwers, Pim; Charurat, Manhattan et al. (2009) Early immunological predictors of neurodevelopmental outcomes in HIV-infected children. Clin Infect Dis 48:338-46
Watts, D H; Lu, M; Thompson, B et al. (2009) Treatment interruption after pregnancy: effects on disease progression and laboratory findings. Infect Dis Obstet Gynecol 2009:456717
Ouyang, David W; Shapiro, David E; Lu, Ming et al. (2009) Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure. AIDS 23:2425-30
Aldrovandi, Grace M; Chu, Clara; Shearer, William T et al. (2009) Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics 124:e1189-97
Dowd, Kimberly A; Hershow, Ronald C; Yawetz, Sigal et al. (2008) Maternal neutralizing antibody and transmission of hepatitis C virus to infants. J Infect Dis 198:1651-5
Pahwa, Savita; Read, Jennifer S; Yin, Wanrong et al. (2008) CD4+/CD8+ T cell ratio for diagnosis of HIV-1 infection in infants: Women and Infants Transmission Study. Pediatrics 122:331-9
Chen, Katherine T; Tuomala, Ruth E; Chu, Clara et al. (2008) No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission. Am J Obstet Gynecol 198:399.e1-5
Mellins, C A; Chu, C; Malee, K et al. (2008) Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women. AIDS Care 20:958-68

Showing the most recent 10 out of 55 publications