The Washington Metropolitan Consortium, under the leadership of Principal Investigator Mary Young, MD, has established a stable cohort of representative HIV infected and uninfected women during the initial funding cycle of the Women's Interagency HIV Study (WIHS). Enrollment figures exceeded the planned enrollment by 7 percent, of which 85 percent have been retained. This cohort has served as the basis for collaborative studies investigating hypotheses that address issues in women's health, HIV disease progression, gynecologic, behavioural and laboratory evaluations of both HIV infected and uninfected women. We propose maintaining this cohort to maximize our ability to address core hypotheses in a prospective fashion. We propose expanding the original core hypotheses to address research questions that have been raised in light of major advances in our understanding of the pathophysiology of HIV and advances in therapeutic treatment options. This will involve maintaining existing collaborations and expanding beyond WIHS to basic science researchers with specific expertise through alternative funding mechanism. Thus, we will maximize access to valuable repository specimens that have been acquired during the initial studies and will be maintained and expanded during WIHS II. This collaborative study has succeeded at both the national and local level because of a high level of committment to the participants, as evidenced by their inclusion in all aspects of protocol development and evaluation. This cohort is now poised to make a significant contribution to women's health and to our understanding of viral-host interactions, and specifically HIV viral pathogenesis. Issues related to transmission, infection and gynecologic health are being addressed and important interactions between behaviours, health care utilization, risk of infection and disease progression are being studied. The new natural history of HIV in the era of highly active antiretrovirals can now be defined. In summary, maintenance of this well characterized, representative cohort of women and its extensive repository of specimens allows for an expansion of our knowledge, not only of HIV but of issues in women's health also.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PRJ-A (O2))
Program Officer
Williams, Carolyn F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgetown University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Sharma, Anjali; Ma, Yifei; Tien, Phyllis C et al. (2018) HIV Infection Is Associated With Abnormal Bone Microarchitecture: Measurement of Trabecular Bone Score in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr 78:441-449
Moran, Caitlin A; Sheth, Anandi N; Mehta, C Christina et al. (2018) The association of C-reactive protein with subclinical cardiovascular disease in HIV-infected and HIV-uninfected women. AIDS 32:999-1006
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Tipton, Laura; Cuenco, Karen T; Huang, Laurence et al. (2018) Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min 11:12
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Rice, Whitney S; Logie, Carmen H; Napoles, Tessa M et al. (2018) Perceptions of intersectional stigma among diverse women living with HIV in the United States. Soc Sci Med 208:9-17
Kelso-Chichetto, N E; Okafor, C N; Cook, R L et al. (2018) Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV. AIDS Behav 22:1411-1422
Adams, Leah M; Wilson, Tracey E; Merenstein, Daniel et al. (2018) Using the Center for Epidemiologic Studies Depression Scale to assess depression in women with HIV and women at risk for HIV: Are somatic items invariant? Psychol Assess 30:97-105
Galárraga, Omar; Rana, Aadia; Rahman, Momotazur et al. (2018) The effect of unstable housing on HIV treatment biomarkers: An instrumental variables approach. Soc Sci Med 214:70-82
Enkhmaa, Byambaa; Anuurad, Erdembileg; Zhang, Wei et al. (2018) Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study. J Lipid Res 59:1967-1976

Showing the most recent 10 out of 633 publications