The NYC/Bronx Consortium is the largest of the six sites of the Women's Interagency HIV and ideally situated to continue its highly successful investigations into HIV infection in women, through both its core activities and its ongoing collaborations with the broader scientific community. Our specific goal as a local site is to provide the operational and scientific support necessary to achieve the specific aims and hypotheses proposed in part A of this application. In so far as future WIHS investigations are predicated upon having a high rate of visit compliance and low missed visit rates, the NYC/Bronx WIHS has a proven superior track record. The NYC/Bronx consortium has also played a strong leadership role in promoting the overall WIHS scientific agenda concentrating on long-term clinical outcomes of natural and treated history (Dr. Anastos) and focused virologic investigations through our Co-PIs for virologic studies (Drs Burger and Weiser). It has extended its scientific reach by attracting prominent collaborators in the field. Our role will be especially strong in continuing investigations of several of the specific aims outlined in part A, including Aim 2, many of which will continue to be led by Dr. Anastos, as well as Aims 3 (with leadership from Dr. Justman), 4 and 5. As a specific local research initiative we propose to extend our previous investigations of quantitative HIV-1 RNA in different biologic compartments in HIV-1 infected women; this project intersects with specific aim 5 by investigating the hypothesis that these gender differences in viral pathogenesis are mediated by female hormones, and biologic compartmentalization of immune function. These investigations, performed at the clinical site of the Bronx/Manhattan WIHS, will have specific emphasis on variations in quantitative HIV-1 RNA, co-receptor utilization, and immune function (CTL responses) in the plasma and genital tract occurring with different patterns of exogenous or endogenous hormones. In addition, through a small number of additional specimens, we will investigate the association of women's hormones with HPV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AI035004-10
Application #
6592023
Study Section
Special Emphasis Panel (ZAI1-HSD-A (S1))
Program Officer
Williams, Carolyn F
Project Start
1993-08-01
Project End
2007-11-30
Budget Start
2003-03-15
Budget End
2003-11-30
Support Year
10
Fiscal Year
2003
Total Cost
$2,601,091
Indirect Cost
Name
Montefiore Medical Center (Bronx, NY)
Department
Type
DUNS #
041581026
City
New York
State
NY
Country
United States
Zip Code
10467
Bekhbat, Mandakh; Mehta, C Christina; Kelly, Sean D et al. (2018) HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling. Psychoneuroendocrinology 96:118-125
Baxi, S M; Greenblatt, R M; Bacchetti, P et al. (2018) Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV. Pharmacogenomics J 18:245-250
Hu, Yirui; Hoover, Donald R (2018) Power Estimation in Planning Randomized Two-Arm Pre-Post Intervention Trials with Repeated Longitudinal Outcomes. J Biom Biostat 9:
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Colie, Christine; Michel, Katherine G; Massad, Leslie S et al. (2018) Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age. J Acquir Immune Defic Syndr 79:573-579
Yang, Jingyan; Sharma, Anjali; Shi, Qiuhu et al. (2018) Improved fracture prediction using different fracture risk assessment tool adjustments in HIV-infected women. AIDS 32:1699-1706
Adimora, Adaora A; Ramirez, Catalina; Benning, Lorie et al. (2018) Cohort Profile: The Women's Interagency HIV Study (WIHS). Int J Epidemiol 47:393-394i
Glesby, Marshall J; Hanna, David B; Hoover, Donald R et al. (2018) Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection. AIDS 32:1643-1650
Belenky, Nadya; Pence, Brian W; Cole, Stephen R et al. (2018) Impact of Medicare Part D on mental health treatment and outcomes for dual eligible beneficiaries with HIV. AIDS Care :1-8
Huck, Daniel M; Hanna, David B; Rubin, Leah H et al. (2018) Carotid Artery Stiffness and Cognitive Decline Among Women With or at Risk for HIV Infection. J Acquir Immune Defic Syndr 78:338-347

Showing the most recent 10 out of 679 publications