The Northwestern University (NU) Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS) addresses the highest research priorities in AIDS research through retention and maintenance of the cohort, collection and repository storage of specimens, and development and implementation of the MACS Research Agenda. Through the leadership we provide and the data and biological specimens we collect, the NU CRS actively contributes to all MACS core protocols and thematic substudies to characterize the long-term, natural and treated history of HIV infection in a cohort of men who report sex with men (MSM). We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and biological specimens. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to evolving scientific opportunities. For the past 30 years, we have maintained a strong AIDS research portfolio that supports basic discovery research into important priority areas in etiology and pathogenesis, behavior and social science, and natural history and epidemiology. The diversity of the work makes possible a broad and multidisciplinary view of AIDS research. Scientific questions take full advantage of the strengths of the MACS, namely, its duration and the continuity of data and specimens that timespan provides. Researchers can distinguish data and specimens from men before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the entire MACS consortium, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the unique resources of the NU Genome Sequencing and Analysis Program, we are able to explore the human genome and define the biological circuits that underlie cellular processes in search of the molecular basis of disease. MACS genomic data are shared among investigators in an interpretable manner and made widely available to the research community through a controlled-access system that reduces the risks of sharing potentially identifying data. Looking ahead, the NU CRS will continue to support a rational, holistic research plan that will provide insight into the evolving biological and psychosocial characteristics of the HIV/AIDS epidemic in MSM. We will build upon our AIDS research portfolio built on a unique cohort, rich with clinical and biological information. We will replace existing cohort members who die or are lost to follow-up using a rolling cohort design. With data obtained through multidisciplinary studies of high scientific quality, we expect to advance research that will help to better manage the care and treatment of people living with HIV/AIDS, and contribute to vaccine development as well as public health policy and interventions.

Public Health Relevance

The Multicenter AIDS Cohort Study (MACS) is the longest ongoing natural and treated history study of people with HIV/AIDS. This ongoing study, which chronicles the biological and psychosocial factors that have shaped the epidemic, tracks HIV disease and its comorbid conditions. The knowledge that we acquire about immune and host restriction factors, the mechanisms of viral persistence, and the impact of treatment and normal aging, will improve the clinical care of people with HIV/AIDS, guide public health public health policy and interventions, and contribute to vaccine development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035039-24
Application #
9044721
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Roe, Joanad'Arc C
Project Start
1993-04-01
Project End
2019-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
24
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Halec, Gordana; Waterboer, Tim; Brenner, Nicole et al. (2018) Serological Assessment of 18 Pathogens and Risk for AIDS-associated Non-Hodgkin Lymphoma. J Acquir Immune Defic Syndr :
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Wu, Minjie; Fatukasi, Omalara; Yang, Shaolin et al. (2018) HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition. AIDS 32:1803-1810
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Armstrong, Nicole M; Surkan, Pamela J; Treisman, Glenn J et al. (2018) Optimal metrics for identifying long term patterns of depression in older HIV-infected and HIV-uninfected men who have sex with men. Aging Ment Health :1-8
Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Maki, Pauline M; Rubin, Leah H; Springer, Gayle et al. (2018) Differences in Cognitive Function Between Women and Men With HIV. J Acquir Immune Defic Syndr 79:101-107
Dutta, Anupriya; Uno, Hajime; Lorenz, David R et al. (2018) Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control 29:1131-1142

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