This is a proposal to continue to document the natural history of untreated and treated HIV infection in: 1) a group of 1637 men-who-have-sex-with-men (MSM) originally recruited in 1984-5; and 2) a group of 363 young Latino and African-American MSM recruited in 2002-3. The men are followed at three clinics (UCLA-Wilshire, UCLA/Harbor Research and Education Institute, and the Gay and Lesbian Center) with an extensive questionnaire eliciting behavioral, medical, and psychosocial information; physical examination; blood collection for concurrent evaluation of HIV status (HIV-negatives), viral load (HIV-positives), levels of T cells subsets, activation markers, and lipids; and assessment of HBV and HCV markers. Equal aliquots of serum, plasma, and cells are stored at the UCLA and the National Repository. The outcome status of 91% of the 1984-5 cohort is known, attributable in part to the outstanding commitment of the staff, most of whom have been with the UCLA center for more than ten years, and several for 20 years. The 2002-3 cohort members are in the process of completing their first follow-up visit. The UCLA site has demonstrated its scientific leadership through leadership roles in the MACS Executive Committee (Detels), chairmanship of the Malignancy (Martinez), and Neuropsychological (Miller) working groups, and leadership roles in flow cytometry (Jamieson), viral testing procedures (Young), and studies of resistance to HIV (Detels). UCLA investigators have been the lead authors on 65 MACS-wide and UCLA center-specific scientific publications since 1998. The objectives of the UCLA MACS Clinical Center are to: 1. Maintain the cohort of 2000 men recruited in 1984-85 and 2002-3 through 2009; 2. Collect specific clinical, behavioral, and psychosocial data and laboratory specimens to meet the scientific objectives of the MACS (see Part A submitted by the CAMACS); 3. Contribute scientific leadership for the overall MACS and extend scientific knowledge about the natural history of untreated and treated HIV disease; and, 4. Promote involvement in the MACS by qualified investigators at UCLA and other institutions. With the assistance of its Community Advisory Board and its outstanding staff, the UCLA Center of the MACS is committed to maintaining the same level of commitment, leadership and follow-up of the cohort through 2009.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035040-15
Application #
7231346
Study Section
Special Emphasis Panel (ZAI1-EB-A (J1))
Program Officer
Huebner, Robin E
Project Start
1993-04-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
15
Fiscal Year
2007
Total Cost
$3,646,355
Indirect Cost
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Wu, Minjie; Fatukasi, Omalara; Yang, Shaolin et al. (2018) HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition. AIDS 32:1803-1810
Armstrong, Nicole M; Surkan, Pamela J; Treisman, Glenn J et al. (2018) Optimal metrics for identifying long term patterns of depression in older HIV-infected and HIV-uninfected men who have sex with men. Aging Ment Health :1-8
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Maki, Pauline M; Rubin, Leah H; Springer, Gayle et al. (2018) Differences in Cognitive Function Between Women and Men With HIV. J Acquir Immune Defic Syndr 79:101-107
Dutta, Anupriya; Uno, Hajime; Lorenz, David R et al. (2018) Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control 29:1131-1142
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504

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